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High-probability grants
According to our matching algorithm, Zhihua Zou is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2007 — 2009 |
Zou, Zhihua |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Encoding of Behaviorally Relevant Olfactory Stimuli @ University of Texas Medical Br Galveston
[unreadable] DESCRIPTION (provided by applicant): Mammals have evolved dual olfactory systems to detect a vast number of odorants as well as pheromones, and to translate chemical information into diverse perceptions and distinct behaviors. Recent studies have shown that both the main and the accessory olfactory systems are involved in detecting both general odors and pheromones, but the distinct roles of each system in mediating different olfactory behaviors remain to be characterized. In addition, despite considerable progress in understanding odor detection, sensory transduction and information coding in both systems, neither the odor stimuli that elicit distinct olfactory behaviors nor the brain neural pathways that mediate odor-specific neural and endocrine responses have been clearly defined. This proposal will develop molecular techniques to identify odorant or pheromone receptors activated by behaviorally relevant olfactory stimuli to test the hypothesis that biologically significant olfactory stimuli are detected by distinct subsets of odorant or pheromone receptors. Identification of behaviorally-activated receptors will allow future studies to: 1) screen different odor fractions and individual odor components to reveal the identity of biologically significant olfactory stimuli, 2) dissect the relative roles of the two olfactory systems in regulating specific olfactory behaviors, and 3) characterize how signals from these receptors are routed in the brain to regulate distinct behaviors. Many olfactory behaviors are robust and stereotyped, and the neural circuits mediating these behavioral responses are largely genetically determined. Knowledge of the neuronal substrates mediating these innate behaviors will aid our understanding of normal human behavior as well as neurodevelopmental disorders such as autism, schizophrenia and drug addiction. [unreadable] [unreadable] [unreadable]
|
0.984 |
2007 — 2009 |
Zou, Zhihua |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Functional Organization of the Olfactory Cortex @ University of Texas Medical Br Galveston
[unreadable] DESCRIPTION (provided by applicant): Loss of smell is one of the first signs of many neurodegenerative diseases and aging disorders. Knowledge of neuronal structure and the pathways of information flow in the brain is important for identifying the cause of smell loss in diseased brains which may lead to early diagnosis and better treatment of the underlying conditions. Studies in the past have uncovered much about the mechanisms of odor detection in the mouse olfactory epithelium and bulb, but little is known about how sensory information is encoded in the cortex. We previously showed that inputs derived from different types of odorant receptors (ORs) are targeted to different but spatially overlapping clusters of cortical neurons and each cortical neuron appears to receive inputs from multiple ORs. Given that each odor molecule is detected in the nose by a combination of different ORs, this proposal will develop and apply genetic and functional approaches to test if inputs from the different ORs activated by the same odorant converge on cortical neurons to determine their response specificity. In Aim 1, we will develop recombinant adeno-associated virus (rAAV) to express different transneuronal tracers. As each bulb glomerulus represents a single type of OR, we will inject different rAAVs into different glomeruli to express a distinct tracer in bulb mitral and tufted cells connected to the injected glomeruli. The tracer will migrate from bulb to cortex to reveal the cortical organization of the corresponding ORs. These studies will test if inputs from the ORs activated by the same odorant converge on cortical neurons. In Aim 2, we will examine if the neurons activated by an odorant are those that receive convergent inputs from its ORs. In addition, we will compare the cortical neurons activated by separate versus combined OR inputs to test if combinations of OR inputs shape the response specificity of cortical neurons. Together, these studies will show how different chemical features detected by different ORs are integrated in the cortex to yield distinct perceptions. The new tracing method developed in this proposal will also be useful to systematically analyze how the stereotyped bulb map is topographically represented in the cortex and if different odor qualities are represented by distinct cortical patterns. The proposed studies are ideally suited for the R21 mechanism. [unreadable] [unreadable] [unreadable]
|
0.984 |