Doris Trauner, M.D. - US grants
Affiliations: | Neurosciences, Pediatrics | University of California, San Diego, La Jolla, CA |
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Doris Trauner is the likely recipient of the following grants.Years | Recipients | Code | Title / Keywords | Matching score |
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1988 — 1994 | Trauner, Doris A | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Neurobehavioral Phenotypes of the Cystinosis Gene @ University of California San Diego Children with infantile nephropathic cystinosis suffer from an autosomal recessive genetic defect that disrupts the lysosomal transport of cystine, producing cystine accumulation in many organs, including kidney, cornea, thyroid gland, and brain. Preliminary studies have identified a specific cognitive impairment in short-term visual memory for both cystinostics and obligate heterozygous carriers of the gene. We propose to perform extensive neurobehavioral, chemical and ophthalmologic studies on additional groups of cystinotic children, their heterozygous parents, and siblings who are potential carriers, as well as appropriate normal, renal disease, and hypothyroid control groups to confirm and specifically define the underlying mechanisms responsible for this cognitive deficit. Such a multidisciplinary approach has the potential to provide unique insights into brain/behavior relationships. This research could establish that certain neuronal populations, i.e. those responsible for the development of short-term visual memory functioning, are particularly susceptible to the accumulation of cystine. Such a discovery is a special relevance for heterozygotic carriers of other genetic disorders, who also may suffer from specific cognitive impairments that as yet are unidentified. |
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1995 — 2000 | Trauner, Doris A | P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
@ University of California San Diego nervous system disorder diagnosis; language disorders; biomedical facility; child (0-11); data collection; child psychology; computer data analysis; language development; behavioral /social science research tag; brain imaging /visualization /scanning; human subject; hearing tests; clinical research; intelligence tests; psychological tests; magnetic resonance imaging; |
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1996 — 2002 | Trauner, Doris A | P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
@ University of California San Diego The Diagnostic Core will provide a framework for the identification and neurobehavioral screening evaluation of subjects entering into the individual projects. Before the state-of-the-art experimental procedures outlined in the Projects can be applied to the study populations, it is crucial to determine whether individual children meet the inclusionary and exclusionary criteria for the group to which they are assigned. In addition, the Core neurological data and screening battery provide a framework in which to better understand athe significance of the experimental data provided in the subprojects. The major responsibilities of the Diagnostic Core are; 1. Identification and induction of experimental and control subjects. 2. Screening of subjects for selection criteria as defined for each research project. 3. Administration and analysis of medical and developmental questionnaires and medical/neurologic examinations. 4. Administration and scoring of a battery of standardized tests to all experimental subjects, and to a subset of controls. 5. Tracking of all subjects form entry to completion of testing. 6. Provision of MRI scans with clinical interpretations and morphometric analysis. 7. Collaboration with Project Investigators to relate these diagnostic findings tot he experimental findings obtained in the Project studies. |
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1997 | Trauner, Doris A | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Neurological Basis of Learning and Language Disorders in Children @ University of California San Diego learning disorders; neurology; infant human (0-1 year); language disorders; child (0-11); neurogenetics; cognition disorders; language development; genetic disorder; metabolism disorder; cognition; behavioral /social science research tag; human subject; clinical research; |
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2003 — 2005 | Trauner, Doris A | P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Center For the Neural Basis of Language and Learning @ University of California San Diego The purpose of this multi-disciplinary Center is to explore the neural bases of language and cognitive development from 7-18 years of age, combining cross-sectional and longitudinal behavioral methods with neural imaging (event-related brain potentials (ERP); functional magnetic resonance imaging (fMRI) to study normal and abnormal brain development, and the alternative forms of brain organization that can emerge under pathological conditions, and the alternative forms of brain organization that can emerge under pathological conditions. Project A focuses on children with Language Impairment (LI); it examines the cognitive and neural correlates of LI, and test competing hypotheses about the processing deficits that underlie this disorder. Project B follows children with focal lesions (FL) to one side of the brain, acquired pre- or perinatally (before 6 months of ages); it will provide behavioral, fMRI and ERP evidence regarding the alternative forms of organization the underlie plastic reorganization in the plastic reorganization in this population. Project C compares Williams Syndrome (WMS), a rare form of mental retardation in which language is especially vulnerable. Project D is new, and constitutes an extension of Project 2 to study children with lesions of later onset in childhood, children with bilateral pathology, and children with slowly evolving lesions due to tumor; the purpose of this project is to increase our understanding of developmental and neurological limits on plasticity. Project E is new, a groundbreaking series of studies using fMRI, including BOLD activation studies of language, spatial processing and spatial attention, as well as perfusion studies of vascular organization. Project F continues our ERP studies of language, spatial cognition and basic auditory-visual processing in all populations. Core A handles administration, data base management, tracking and statistical consultation.. Core B is responsible for recruitment of controls, and handles screening, diagnosis and induction of all populations. Core C is a new joint behavioral testing facility that handles language and behavioral testing (excluding ERP and fMRI) for all populations, including language transcription. |
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2003 — 2007 | Trauner, Doris A | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Brain Structure and Cognition in Cystinosis @ University of California San Diego DESCRIPTION (provided by applicant): There has been increasing interest in the role of genetic influences on behavior and cognition in the last decade. Studies of such genetic conditions provide us with a unique opportunity to study gene-behavior and brain-behavior relationships in a genetically well-defined population. Nephropathic cystinosis is a genetic disorder in which a specific cognitive profile of visual spatial dysfunction, with spared visual perceptual function, intelligence, and language, has been documented. Brain MRI scans and neuropathological data have suggested a possible defect in myelination of the white matter. The mechanisms underlying these problems, and the course of the dysfunction over time are not known. The proposed study will use a longitudinal approach to study visual perceptual and visual spatial function over time in children and adolescents with cystinosis as well as controls; to perform serial MR/scans on children and adolescents with cystinosis; and to conduct morphometric analyses of the MRI scans to identify regional structural differences between cystinosis and control brains, in particular in the white matter. The study will take advantage of the already existent large database of cognitive studies in the cystinosis population obtained by this laboratory, so that subjects previously tested will undergo repeat testing to provide longitudinal information about changes in cognitive function and brain structure as the child gets older. The results of this study provide the potential for understanding the role of early metabolic and genetic dysfunction on subsequent brain development, both structural and functional, and for determining whether the presence of the metabolic disorder can produce a progressive deleterious effect on brain function. The study results may also provide a basis for developing early interventions for children "at risk" for cognitive deficits because of the presence of a genetic disorder. |
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2003 — 2007 | Trauner, Doris A | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Neuro-Cognitive Outcome After Early Focal Brain Damage @ University of California San Diego DESCRIPTION (provided by applicant): A great deal can be learned about plasticity in the developing human nervous system by studying children who incur brain insults during critical periods of brain development. Damage to the developing brain may have a very different impact on cognition than would damage to the fully developed brain. The focus of this study will be to evaluate the role of seizures and of epileptiform brain activity on cognitive function in children with early focal brain damage (FL). The study proposes to explore issues of plasticity and reorganization in the developing human brain by studying children who suffered very early unilateral brain damage from stroke or hemorrhage, incurred prior to or at birth. The specific aims of the project are 1) to determine the impact of seizures and of epileptiform brain activity on cognitive outcome in children with early focal brain damage; 2) to determine whether epileptiform electroencephalographic (EEG) abnormalities in the FL population are stable over time, or get worse or better with time, and whether changes in the EEG over time correlate with changes in cognitive function; 3) to identify the extent and limits of plasticity in this population, and the role of seizures or epileptiform brainwave activity in limiting plasticity. Three groups of children between the ages of 8 and 12 years with pre- or peri-natal unilateral brain lesions in the middle cerebral artery distribution from stroke or hemorrhage, and matched controls, will receive neuropsychological, behavioral, and adaptive function assessments, including tests of intelligence, language, visual spatial skills, attention, memory, academic achievement, and executive function. Subjects will also have EEGs to assess the effects of epileptiform abnormalities on cognitive function, and brain MRI scans to determine the volume and location of the lesions. The 3 FL groups will consist of 20 children with a history of seizures, 20 children without seizures but with epileptiform EEG abnormalities, and 20 children with no seizures and normal EEGs. The results of these investigations should provide a better understanding of the role of seizures and epileptiform brain activity on cognitive function during brain development, as well as potential limitations on plasticity in the developing human brain. The findings may further serve as a basis from which to design more effective interventions for children at risk for cognitive dysfunction because of early brain damage. |
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2004 — 2008 | Trauner, Doris A | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Language Development Following Early Focal Brain Injury @ University of California San Diego [unreadable] DESCRIPTION (provided by applicant): We propose prospective, longitudinal studies of the relationship between early brain injury and language development from birth to age 5, building on 15 years of research on language and cognitive outcomes in children with congenital left- or right hemisphere injuries (due primarily to pre- or perinatal stroke), using state-of-the-art methods for structural imaging and lesion-symptom mapping. The latter include a new method called Voxel-based Lesion Symptom Mapping (VLSM, Bates et al., Nature: Neuroscience, 2003) developed in our laboratories, which permits graded color maps of the relationship between behavioral measures and lesion sites, applied for the first time to children with lesions. New diffusion-tensor imaging (DTI) methods will be used to examine changes in connectivity that may be attributable to early brain injury and subsequent reorganization. Longitudinal studies of language and related non-linguistic functions will be conducted from 8 to 60 months of age, the period in which most of language is acquired, from the first signs of babbling to the mastery of grammar and discourse. Our previous studies suggest that this period is a "window of plasticity", in which most children with early unilateral injuries start with serious delays, but move into the normal to low-normal range on language measures. In children with congenital, unilateral lesions, we will attempt to extend a series of important and surprising findings regarding the specific lesion sites associated with initial delays in babbling, word comprehension, gesture, word production, and grammar, and to examine the trajectories of language and visual spatial development in children with early focal brain damage. Neuroanatomical correlates of milestones, trajectories, delays and recovery from delay will be established based on 3-dimensional lesion reconstruction, VLSM and DTI. For all children with brain injuries, scans will be obtained at two points: on entry into the study (between 6 and 36 months), and at 5 years of age. These two data points will permit within-subject analyses of the initial state of the system with any changes in neuroanatomy that may be related to lesion type and/or to degrees of success or failure in language development. Scans will also be obtained for age- and gender-matched controls at age 5, permitting an assessment of structural alterations due to early injury and subsequent reorganization, alterations which also may correlate with degree and timing of success in language. The new information gained from these studies will enhance our understanding of the timing of changes associated with plasticity in the developing nervous system, as well as defining associations and dissociations in linguistic and visual spatial development. Knowledge gained in this study may form the basis for more effective interventions to help improve neurodevelopmental outcome of children with brain damage in the future. [unreadable] [unreadable] |
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2005 — 2007 | Trauner, Doris A | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Childhood Absence Epilepsy: Rx, Pk-Pd-Pharmacogenetics @ University of California San Diego |
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2005 — 2007 | Trauner, Doris A | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Mitochondrial Function in Cystinosis Myopathy @ University of California San Diego |
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2006 | Trauner, Doris A | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Neurological Basis of Language and Learning Disorders @ University of California San Diego |
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2008 — 2010 | Trauner, Doris A | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Clinical Trial: Childhood Absence Epilepsy: Rx, Pk-Pd-Pharmacogenetics @ University of California San Diego 0-11 years old; Absence Epilepsy; Absence Seizures; Anticonvulsant Agent; Anticonvulsant Drugs; Anticonvulsants; Anticonvulsive Agents; Anticonvulsive Drugs; CRISP; Child; Child Youth; Childhood Absence Epilepsy; Children (0-21); Clinical Trials; Clinical Trials, Unspecified; Computer Retrieval of Information on Scientific Projects Database; Epilepsy, Minor; Funding; Grant; Human, Child; Incidence; Institution; Investigators; Juvenile Absence Epilepsy; NIH; National Institutes of Health; National Institutes of Health (U.S.); Petit Mal Convulsion; Petit Mal Epilepsy; Pharmacogenetics; Pykno-Epilepsy; Pyknolepsy; Rate; Research; Research Personnel; Research Resources; Researchers; Resources; Seizure Disorder, Absence; Seizures; Source; Toxic effect; Toxicities; United States National Institutes of Health; children; clinical investigation; petit mal seizure; youngster |
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2008 — 2012 | Trauner, Doris A | P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
@ University of California San Diego Core A. ADMINISTRATIVE AND STATISTICAL CORE The purpose of the Administrative and Statistical Core is to provide the foundation upon which the proposed program project is built. This Core serves several functions vital to the implementation of the proposed studies. Core A is responsible for the following scientific and administrative functions: (1) Coordination of communications and scientific activity among the various projects and cores; (2) Coordination of the daily functioning of a complex interdisciplinary research activity; (3) Budgetary planning and control; (4) Data base management including all aspects of subject scheduling, tracking, and data security, as well as rules and procedures governing data sharing and joint publication policies; (5) Subject identification and initial screening; (6) Statistical consultation and collaboration including the development and/or utilization of analytic procedures tailored to the special problems that are encountered in the study of rare populations as well as the co-ordination of methodologies that result from interdisciplinary collaborations. Participants in the Program Project will be children ages 7 through 10 years 11 months in the following groups: Typically Developing Controls (TD), Specific Language Impairment (LI), Peri-natal Focal Lesion (FL), High Functioning Autism (HFA), and Williams Syndrome (WS). Subjects will be identified by Core A, screened and inducted into the study by Core B, and undergo MRI scans in Core C. Data from all subjects will be utilized by all Projects to test Project hypotheses. Based on our 20 years of experience with the administration of a large multidisciplinary research center, we have administrative procedures in place that are necessary to run this complex program project grant, and that will sustain an industrious and productive research center over the next 5 years. |
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2008 — 2012 | Trauner, Doris A | P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Center For the Study of the Neural Bases of Language and Learning @ University of California San Diego DESCRIPTION (provided by applicant): The purpose of this multidisciplinary Center is to explore the neural bases of language and cognitive development in children, combining cognitive/behavioral methods with structural brain imaging (quantitative MRI analyses and diffusion tensor imaging) and event-related brain potentials (ERP), to study normal and abnormal brain development, and the alternative forms of brain organization that can emerge under pathological conditions. Our extensive body of behavioral work, coupled with advances in neuro-imaging methods, has positioned us to begin the investigation of a new set of critical issues that are the basis for the proposed research: 1) specific sensory, perceptual and attentional underpinnings of the observed deficits;2) relationships between primary deficits and impairment of higher cognitive functions such as language and social communication;and 3) the emerging structural organization of the neural systems that support these functions. The populations to be studied are children with: typical development (TD);Specific Language Impairment (LI);Early Unilateral Focal Brain Lesions (FL);High Functioning Autism (HFA);and Williams Syndrome (WS). Project 1 will examine sensory and perceptual processing using EEG/ ERPs to determine whether specific and differential profiles exist between typically developing children and our clinical populations, how they map onto respective neural structures, and how these profiles relate to higher cognitive functions. Project 2 will examine the integrity of attention and working memory (WM) in children with neuro-developmental disorders;alterations in brain spatial structure associated with differences in these domains;and the relationship of spatial attention and WM function to both early sensory processing and more complex levels of cognition. Project 3 will examine affect and social communication, and will utilize neuro-imaging studies to correlate brain structural differences with competence in these areas. Project 4 will examine higher level language and literacy skills in the context of early sensory processing capacities, attention/WM, and social communication, as well as correlate outcomes from volumetric analyses of specific brain regions with language and literacy abilities. Core A will provide the Center infrastructure, administrative organization, subject identification/recruitment, database functions, and statistical support. Core B will provide baseline screening, experimental testing, and subject tracking. Core C will conduct MRI scanning for all subjects, and provide the Projects with quantified measures of specific cortical/subcortical structures and white matter tracts. The state of the art imaging techniques proposed in Core C will allow us to obtain an excellent overview of the neuroanatomical features in the clinical populations to be studied. The "value-added" factor of integrating cognitive studies with structural imaging and ERP analyses in a closely interrelated set of studies is enormous, and allows for maximum efficiency in use of time and funds. The clinical relevance of the studies proposed is also very significant;findings from the proposed studies may lead to earlier diagnosis and intervention for specific cognitive deficits, and interventions that are more directly targeted to the underlying sensory, perceptual or cognitive deficit rather than to the final common denominator (e.g., language impairment). |
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2008 — 2012 | Trauner, Doris A | P50Activity Code Description: To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes. |
Spatial Attention and Working Memory @ University of California San Diego 0-11 years old; 21+ years old; Adult; Affect; Area; Attention; Auditory; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; Base of the Brain; Behavior; Behavioral; Beuren syndrome; Birth; Body Tissues; Brain; Brain region; Child; Child Youth; Childhood; Children (0-21); Clinical; Cognition; Cognitive; Cognitive Disturbance; Cognitive Impairment; Cognitive decline; Cognitive deficits; Cognitive function abnormal; Collaborations; Competence; Complex; Contiguous Gene Syndrome, Williams; Cues; Development; Diffusion MRI; Diffusion Magnetic Resonance Imaging; Diffusion Weighted MRI; Disease; Disorder; Disturbance in cognition; Dysfunction; Early Diagnosis; Early Intervention; Early Intervention (Education); Elfin Facies Syndrome; Encephalon; Encephalons; Fanconi Schlesinger syndrome; Fanconi-Schlesinger syndrome; Functional disorder; Gestures; Goals; Human, Adult; Human, Child; Impaired cognition; Impairment; Kanner's Syndrome; Language; Language Development; Language Tests; Lead; Learning; Lesion; Linguistic; Linguistics; Link; Location; Measures; Mediating; Memory Deficit; Memory impairment; Memory, Immediate; Memory, Short-Term; Memory, Shortterm; Mind; Modality; Models, Theoretic; Nature; Nervous; Nervous System, Brain; Neurodevelopmental Disorder; Neurological Development Disorder; Oral; Parietal; Parturition; Pathology; Pathway interactions; Pattern; Pb element; Perception; Persons; Physiopathology; Population; Principal Investigator; Process; Programs (PT); Programs [Publication Type]; Purpose; Sensory; Sensory Process; Short-Term Memory; Speech; Stimulus; Structure; Testing; Theoretical model; Tissues; Visual; Voice; Williams Barratt syndrome; Williams Syndrome; Williams syndrome (WMS, WS); Williams-Barratt syndrome; Williams-Beuren Syndrome; Williams-Beuren syndrome (WBS); Writing; acquiring language skills; adult human (21+); auditory stimulus; behavior measurement; behavioral measure; behavioral measurement; children; cognitive dysfunction; cognitive function; cognitive loss; cognitively impaired; developmental disease/disorder; developmental disorder; diffusion tensor imaging; disease/disorder; early detection; elfin-facies hypercalcemia syndrome; focal brain damage; frontal cortex; frontal lobe; gray matter; heavy metal Pb; heavy metal lead; hypercalcemia-peculiar facies-supravalvular aortic stenosis syndrome; hypercalcemia/Williams-Beuren syndrome; idiopathic hypercalcemia-supravalvular aortic stenosis syndrome; inattention; inattentiveness; insight; interest; language acquisition; language learning; mental retardation-typical facies-aortic stenosis syndrome; neural; pathophysiology; pathway; pediatric; prevent; preventing; programs; rehearsal; relating to nervous system; remediation; skills; social; social communication; specific language impairment; substantia alba; substantia grisea; white matter; working memory; youngster |
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