Area:
Basal Ganglia, Neurodegeneration, Parkinson's Disease
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Joshua A. Goldberg is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2005 — 2006 |
Goldberg, Joshua A |
F32Activity Code Description:
To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Mechanisms of Synchrony in Striatal Cholinergic Neurons @ University of Texas San Antonio
DESCRIPTION (provided by applicant): Parkinsonism is attributed to an imbalance in the dopaminergic-cholinergic tone to the striatum. The primary source of acetylcholine to the striatum is the tonically active cholinergic interneurons. Converging lines of evidence suggest that these neurons form a synchronized network that modulates striatal output and learning. The goal of this study is to reveal the underlying mechanisms of synchrony in this network. Preliminary evidence suggests that these neurons synchronize when bursting, and that their bursting depends on calcium-dependent potassium currents. Voltage and current clamp recording techniques in conjunction with pharmacological treatments will be used in rat striatal slices to identify the calcium channels that are coupled to these potassium currents. Calcium imaging will be used to study the distribution of these channels at the soma and proximal dendrites. Spontaneous and evoked cholinergic synaptic currents will be characterized in slices of bursting neurons. Dual recordings will be used to search for chemical and electrical synapses and to study short-term synaptic plasticity. Phase response functions and synaptic currents will be measured and used to predict network synchrony according to the theory of weakly coupled oscillators.
|
0.931 |