Bradley C. Donohue - US grants

[unreadable] DESCRIPTION (provided by applicant): [unreadable] Although greater than half of parents involved in child family service agencies have evidenced drug abuse, no treatment outcome studies have explicitly been conducted in this population. Moreover, the lack of controlled treatment outcome research in child protective service settings, particularly within child neglect, is well documented. Of the very few outcome studies that have been conducted in child neglecting parents, almost exclusively mothers, the home-based behavioral therapies appear to be particularly promising. The specific aims of this Stage IA/IB study are to: (1) develop the first family-based behavioral therapy treatment manual to explicitly address drug abuse within the context of child neglect, (2) develop accompanying protocol adherence measures, including video scenarios depicting effective implementation of the developed treatment procedures, (3) train program staff to effectively use the developed interventions, (4) examine the reliability, feasibility and clinical utility of the developed manual, as well as the developed method of protocol adherence in clinical case trials involving drug abusing mothers who have evidence child neglect, (5) conduct a controlled comparison of the developed behavior therapy and "treatment as usual" (TAU) Family Services (random assignment of participants to experimental conditions), (6) utilize structured clinical interviews to formally diagnose mothers as drug abusing or drug dependent, as well as standardized methods to assess severity of child neglect, (7) maintain standardization and uniformity of treatments by incorporating treatment manuals, therapist protocol checklists, structured supervision of therapists, assessment of treatment protocol adherence via objective review by independent raters, standardized program introduction during all initial treatment sessions, and equal duration of treatments, (8) utilize objective assessment methods for both child maltreatment (e.g., safety assessment tours of participant homes), and presence of drug use (e.g., urine drug assay tests), as well as standardized measures in the assessment of illicit drug use frequency, child maltreatment, parenting behavior, conduct, and family functioning, (9) examine the initial efficacy of the developed behavioral therapy, as compared with TAU (pre/post assessment), as well as assess durability of study findings (pre/FU assessment). [unreadable] [unreadable] [unreadable]

DESCRIPTION (provided by applicant): Substance abuse is both dangerous and highly prevalent in collegiate student athletes (SAs), leading it to be considered a Public Health Concern by leading researchers in the field. Although treatments have yet to evidence reductions in substance use in SAs diagnosed with substance abuse or dependence, Family Behavior Therapy offers great promise. In the proposed study we will evaluate the efficacy of this intervention in a controlled trial involving 157 SAs who are referred for problems associated with drug and/or alcohol use. FBT will target (a) illicit drug and alcohol use, (b) risk of HIV and STDs, (c) sport performance, and (d) co- morbid psychiatric problem behaviors. The controlled comparison will be conducted between FBT and treatment as usual (TAU), and include (1) utilization of a psychometrically validated structured interview to formally diagnose substance abuse and dependence; (2) standardization and uniformity of treatment; (3) objective biological methods to assess the presence or absence of drug use, (4) psychometrically validated measures to assess illicit drug and alcohol use frequency, clinical problem behaviors, problems in the relationships of SAs with peers, coaches, family and teammates, co-morbid psychiatric symptoms; and risk of HIV/STDs; (5) examination of the efficacy of FBT, as compared with TAU, utilizing assessors who are blind to treatment assignment (pre/post), and (6) 4-month follow-up to assess durability of study findings. Outcome data will be analyzed using repeated measures multivariate analyses, intent to treat will be used to manage missing data, and multi-level models will address potential homogeneity of error variance resulting from nesting or clustering of data. Participants who are assigned to FBT are expected to demonstrate significantly better outcomes than participants who are assigned to TAU from baseline to post-treatment, and from baseline to 4- mo. FU, in 1) substance use (alcohol and illicit drug use frequency, presence/absence of drug use), 2) risk of HIV/STDs, 3) co-morbid psychiatric symptoms, 4) problems interfering with sport performance, and 5) quality in relationships with teammates, coaches, peers and family. Controlled evaluation of an evidence-supported substance abuse treatment program in SAs would be a significant scientific advancement, providing mental health professionals with an evidence-based health care option for this vulnerable population. The proposed study is expected to lead to a substantial paradigm shift in 1) development of substance abuse treatment within the burgeoning field of clinical sport psychology, 2) adoption of family-based models when treating substance abuse in campus counseling centers, and 3) establish a base in which to apply these concepts to new fields. PUBLIC HEALTH RELEVANCE: Participation in collegiate athletics is generally a very positive experience. However, collegiate student athletes (SAs) are at very significant risk to engage in dangerous misuse of illicit drugs and alcohol. Prevention programs have demonstrated efficacy in decreasing alcohol use in SAs, particularly when parents are involved. However, these programs were not designed to manage substance abuse or dependence. Also problematic, campus counseling programs are often ill equipped to manage the culture of athletics, are not family-based, and notoriously rely upon non-evidence-based treatments. The proposed study would permit controlled development of the first comprehensive behavioral treatment to address this very significant problem, having immediate implications for more than 2.5 million students involved in competitive collegiate sports.