Eran Zaidel - US grants
Affiliations: | University of California, Los Angeles, Los Angeles, CA |
Area:
Hemispheric specialization and interactionWebsite:
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Eran Zaidel is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 1979 — 1984 | Zaidel, Eran | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Hemispheric Specialization of Higher Functions in Man @ California Institute of Technology |
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| 1985 — 1993 | Zaidel, Eran | K02Activity Code Description: Undocumented code - click on the grant title for more information. K05Activity Code Description: For the support of a research scientist qualified to pursue independent research which would extend the research program of the sponsoring institution, or to direct an essential part of this research program. |
Hemispheric Specialization of Higher Functions in Humans @ University of California Los Angeles This is a request for an ADAHMA RSDA focusing on hemispheric specialization and interaction at the interface of language and cognition. A convergent research program is outlined which studies neurological patients and normal subjects and combines behavioral, anatomical and physiological methods. Technological developments include a powerful computer-based laboratory for laterality research and a eye-tracker with scotoma simulator for hemispheric occular scanning without attachments to the eye. Theoretical work will continue on behavioral models of laterality effects and conditions for parallel independent information processing in the two hemispheres. One set of experiments will study independent lexical access and organization, syntactic and pragmatic competence and associated cognitive abilities in each of the two hemispheres. A second set of experiments will analyze individual differences in regional patterns of callosal connectivity using behavioral, anatomical and physiological measures, in relation to cognitive profile, handedness and gender. Biological and environmental conditions that change hemispheric function and callosal connectivity will be investigated. A third set of experiments investigates issues of monitoring and control in interhemispheric relations, including learning, metacognition and error correction. Results promise better understanding and possible control of cognitive pathology due to abnormal cerebral activation or faulty interhemispheric communication. The data will contribute to theoretical cognitive neuroscience by understanding how language is organized in the brain and how independent, parallel cortical processing modules interact. Plans for professional growth include (1) Collaborative research with other psychologists, linguists, and neuroscientists, (2) intensive study of neuroanatomy, neurophysiology and statistical analysis, and (3) tutorial visits to other labs to study techniques of event-related potentials, magnetic resonance imaging, clinical neurology, and cognitive psychology. |
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| 1985 — 1994 | Zaidel, Eran | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hemispheric Specialization and Interaction in Humans @ University of California Los Angeles A research program is outlined dealing with hemispheric specialization at the interface of language and cognition. A convergent approach is proposed combining three experimental populations and three broad types of experimental paradigms. The subjects include (i) commissurotomy (split-brain) patients, (ii) hemisphere-damaged patients and, (iii) normal children and adults. The techniques include (i) continuous viewing of complex lateralized visual stimuli, (ii) metabolic, blood flow and magnetic real time indices of cerebral activation, (iii) more traditional paradigms of hemifield tachistoscopy, dichotic listening and dual task interference. Complementary models of hemispheric specialization are developed, motivated by the clinical populations and applied to the normal brain. One set of hemifield decision and facilitation experiments illustrates the "direct access" model; a second set of dichotic listening experiments illustrates the "callosal relay" model; and a third set studies types, development and modulation of interhemispheric interaction. A fourth set of experiments continues the analysis of hemispheric differences in lexical representation and organization, and compares hemispheric specialization for early, preattentive stages of information processing with specialization for later, conscious processes. The fifth set completes the comparison between hemispheric specialization in the three experimental populations for more complex linguistic and nonlinguistic abilities whose model theoretical status remains to be determined. |
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| 1992 — 1993 | Zaidel, Eran | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Alcohol, Nicotine, and Interhemispheric Relations @ University of California Los Angeles APPLICANT'S ABSTRACT: This project will evaluate the acute effects of the common psychoactive drugs alcohol and nicotine on hemispheric functions and interhemispheric communication. Do alcohol or nicotine selectively enhance or depress function-specific modules within one or the other hemisphere in normal subjects? Do these drugs modulate the connectivity of specific communication or control channels in the corpus callosum? Effects of drugs on hemispheric functions will be assessed by tasks that can be performed independently in either hemisphere. Effects of drugs on interhemispheric communication will be assessed by tasks that require callosal transfer of sensory and control information. Comparison between the effects of the drugs in split-brain patients and normal subjects will further help separate drug effects on hemispheric functions from effects on cross- callosal transfer. Five types of interhemispheric transfer tasks will be used. 1) Motor transfer; 2) Sensory visual transfer of color, orientation, and shape; 3) Sensory auditory transfer; 4) Semantic transfer; and 5) Transfer of inhibition from one hemisphere to the other. Within-hemifield presentations of these tests provide measures of hemispheric competence. Together, these tasks tap visual and auditory, linguistic and nonlinguistic, right and left hemisphere functions. The findings will help clarify the acute effects of alcohol and nicotine on brain and normal cognitive functions. The data on modulation of hemispheric function and interhemispheric interaction may have clinical implications for functional recovery following localized lesions.Results will also have theoretical cognitive neuropsychological implications for our understanding of modular organization and intermodular communication in the brain. |
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| 1994 | Zaidel, Eran | K05Activity Code Description: For the support of a research scientist qualified to pursue independent research which would extend the research program of the sponsoring institution, or to direct an essential part of this research program. |
Hemispheric Specialization of Higher Functions @ University of California Los Angeles This is a request for an ADAHMA RSDA focusing on hemispheric specialization and interaction at the interface of language and cognition. A convergent research program is outlined which studies neurological patients and normal subjects and combines behavioral, anatomical and physiological methods. Technological developments include a powerful computer-based laboratory for laterality research and a eye-tracker with scotoma simulator for hemispheric occular scanning without attachments to the eye. Theoretical work will continue on behavioral models of laterality effects and conditions for parallel independent information processing in the two hemispheres. One set of experiments will study independent lexical access and organization, syntactic and pragmatic competence and associated cognitive abilities in each of the two hemispheres. A second set of experiments will analyze individual differences in regional patterns of callosal connectivity using behavioral, anatomical and physiological measures, in relation to cognitive profile, handedness and gender. Biological and environmental conditions that change hemispheric function and callosal connectivity will be investigated. A third set of experiments investigates issues of monitoring and control in interhemispheric relations, including learning, metacognition and error correction. Results promise better understanding and possible control of cognitive pathology due to abnormal cerebral activation or faulty interhemispheric communication. The data will contribute to theoretical cognitive neuroscience by understanding how language is organized in the brain and how independent, parallel cortical processing modules interact. Plans for professional growth include (1) Collaborative research with other psychologists, linguists, and neuroscientists, (2) intensive study of neuroanatomy, neurophysiology and statistical analysis, and (3) tutorial visits to other labs to study techniques of event-related potentials, magnetic resonance imaging, clinical neurology, and cognitive psychology. |
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| 1994 — 1998 | Zaidel, Eran | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hemispheric Specialization and Interaction @ University of California Los Angeles The proposed experimental and theoretical developments aim to elucidate the nature and scope of hemispheric specialization, independence, interaction and control in the human brain. Coordinated experiments will be carried out with normal subjects and neurological patients using convergent behavioral, anatomical and physiological methods and addressing general issues in cognitive neuroscience, notably concerning modularity and intermodular communication. Technological developments include a computerized system for human neuropsychological testing including an eyetracker-based hemianopsia simulator for analyzing hemispheric differences in processing complex visual arrays. A core set of behavioral experiments (1) explores individual differences in hemispheric specialization in attention, perception and language, (2) contrasts different degrees of hemispheric independence, including independence of strategies, resources and priming, and (3) analyzes the control of parallel processing in the two hemispheres. In the second part of the proposal, the same experiments will be administered to (1) patients with chronic complete cerebral commissurotomy, (2) patients with agenesis of the corpus callosum, and (3) patients with partial callosotomy, both pre- and post-surgically. In the third part of the proposal we will study the anatomical correlates of the same behavioral measures of interhemispheric relations. We will (1) analyze the cytoarchitecture of asymmetric cortex and its relation to regional callosal morphology and morphometry in post mortem, and (2) analyze morphometric-behavioral correlations between "volumes-of- interest" and regional callosal morphometry from in-vivo MRI in normal subjects who also received the behavioral measures. In the fourth part we will study the physiological correlates of the same behavioral measures by monitoring trial-based topographic EEG as an index of hemispheric activation (alpha suppression) and interhemispheric interaction (coherence). The physiological measures will be applied to the normal subjects as well as to the patient populations. Results promise better understanding and possible control of pathology due to abnormal cerebral activation or impaired interhemispheric communication. The data will contribute to theoretical cognitive neuroscience by clarifying how independent, parallel cortical processing modules of attention, perception, and language interact. |
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| 1998 | Zaidel, Eran | P41Activity Code Description: Undocumented code - click on the grant title for more information. |
Hemispheric Specialization and Interhemispheric Relations: Language @ University of California Los Angeles This proposal is part of a research program that aims to clarify (1) hemispheric specialization and independence. (2) interhemispheric spheric interaction, and (3) interhemispheric control. These mechanisms of interhemispheric relations address three central theoretical concepts in cognitive neuroscience: modularity of processing. intermodular communication. and behavior. Specific Aims A basic thesis of this research program is that the two cerebral hemispheres constitute parallel, semi-independent. information processing systems which interact through function-specific cortical channels in the corpus and through less specific subcortical channels. In the following proposal we analyze the anatomical basis of the relationship between hemispheric specialization and interhemispheric interaction by analyzing the anatomical substrates of language gifted asymmetric cortex and of the callosal channels that interconnect it. We focus on two regions corresponding to two of our main behavioral tasks; Broca's area, which is specialized for phonetic processing in dichotic listening to nonsense consonant-vowel syllables (CVs) and; Wernicke's area, which is specialized for lateralized lexical decision. Since we believe that the different behavioral measures draw upon these different cortical regions, we hypothesize that different behavioral measures will also be associated with different callosal channels. Furthermore, we expect the anatomical asymmetry of cortical modules will be negatively correlated with the size of the callosal channel that interconnects it. Another goal is to map the organization of callosal channels and their relationship to hemispheric specialization. |
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| 2000 | Zaidel, Eran | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hemisperic Specialization and Interaction @ University of California Los Angeles DESCRIPTION: (Adapted from the Investigator's Abstract) The proposed research program aims to unravel the persisting mystery of hemispheric specialization and interhemispheric interaction in the human mind/brain. We will carry out coordinated experiments with normal subjects, hemisphere damaged patients, and split brain patients, using convergent behavioral and physiological methods. The program addresses general issues in cognitive neuroscience concerning modularity, intermodular communication, and control of parallel processing in independent modules. A core set of three lateralized behavioral experiments will investigate (1) hemispheric specialization and interdependence, (2) explicit and implicit interhemispheric transfer, and (3) interhemispheric control of parallel processing. Each experimental paradigm includes an intrahemispheric component for studying hemispheric independence, and an interhemispheric component for studying interhemispheric interaction and control. The same behavioral experiments will be administered to patients with (1) complete cerebral commissurotomy, (2) agenesis of the corpus callosum, and (3) partial callosotomy, both pre- and post-surgically. The first paradigm is dichotic listening to words and accents. It measures complementary left hemispheric specialization for linguistic phonetic analysis and right hemisphere specialization for social/pragmatic aspects of communication. The second paradigm is lexical decision of lateralized targets with distractors in the opposite visual hemifield. It measures independent word recognition, independent error monitoring in the two hemispheres, and implicit priming across the hemispheres. The third paradigm is perceptual matching of letters by shape or by name within and between the hemispheres. It measures the ability of the hemispheres to process information in parallel in complex tasks. Together, the three experimental paradigms developed in this proposal provide a compact but comprehensive and exquisitely sensitive battery of tests of interhemispheric relations. This battery can then be used for studying individual or group differences in interhemispheric relations in normal and pathological populations, such as acquired aphasia, congenital dyslexia and schizophrenia. Results promise better understanding and possible control and reversal of pathology due to abnormal cerebral activation or impaired interhemispheric communication. |
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| 2001 — 2010 | Zaidel, Eran | P41Activity Code Description: Undocumented code - click on the grant title for more information. R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Hemisperic: Specialization and Interaction @ University of California Los Angeles This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is part of a research program that aims to clarify (1) hemispheric specialization and independence, (2) interhemispheric interaction, and (3) interhemispheric control. These mechanisms of interhemispheric relations address three central theoretical concepts in cognitive neuroscience: modularity of processing, intermodular communication, and control of parallel modular processes. A core set of progressively complex lateralized behavioral paradigms developed in our laboratory have been designed to (1) explore individual differences in hemispheric specialization in attention, perception and language;(2) contrast different degrees of hemispheric independence, including independence strategies, resources and priming, and (3) analyze the control of parallel processing in the two hemispheres. These experiments range from sensorimotor integration in simple reaction time through phonetic perception and letter identification to complex word recognition. Each experimental paradi gm includes an intrahemispheric component for studying hemispheric independence, and an interhemispheric component for studying interhemispheric interaction and control. These experiments have been administered to normal subjects and to patients with complete cerebral commissurotomy, agenesis of the corpus callosum and patients with partial callosotomy both pre- and post surgically as well as with patients with selected lateralized lesions to examine the role of the right hemisphere in natural language processing. This proposal focuses on the study of the anatomical correlates with some of the same above mentioned behavioral measures of interhemispheric relations. With this approach we combine sophisticated cognitive theory and methodology on the one hand, with in-depth neuroscientific analysis that incorporates anatomical, physiological and clinical behavioral techniques, data and theory on the other. Thus, we use converging studies of normal subjects and parallel measures of brain structure (MRI), brain function, and behavior. |
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