Area:
Development, visual system
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High-probability grants
According to our matching algorithm, Elizabeth A. Debski is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1987 |
Debski, Elizabeth A |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Signal Convergence in the Three-Eyed Frog |
0.97 |
1992 — 1996 |
Debski, Elizabeth |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
The Visual System: Modulation of Nmda Receptor Activity @ University of Kentucky Research Foundation
The ability to correctly perceive the physical world around us is to a large part dependent on hooking the eye up to the brain in a very precise fashion. Dr. Debski's goal is to understand the process whereby the neurons from the eye choose the cells in a target structure with which to connect. In order to study the problem of how the eye connects to the brain, Dr. Debski will use the visual system of a amphibian model system. In this system, the eye connects to the optic tectum, the main visual area of the animal. There the neurons from the eye form a map of the visual space. This brain structure is similar to the visual maps found in mammals and primates. One of the distinct advantages of the amphibian is that development of the visual system occurs during a stage when it is readily accessible. Therefore the developmental processes which lead to the formation of these maps can be studied. Dr. Debski's study will focus on the NMDA receptor, a type of receptor found on some neurons. This receptor is known to play as role in determining where the optic tectum neurons from the eye connect. She will determine whether the activity of this receptor can be modulated by the neurotransmitters glycine, serotonin and VIP and to what extent the latter two of these transmitters are found in the visual system and therefore are likely to provide such modulation in the intact animal. Dr. Debski will also determine the degree to which the developing system changes with respect to NMDA receptor activity and serotonin- and VIP-like immunoreactive neurons as it matures. The results from these studies will allow us to better understand how to modulate NMDA receptor activity as a means to correct error in visual connectivity when they occur.***//
|
0.915 |
1996 — 2000 |
Debski, Elizabeth |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
The Role of Activity in Afferent-Mediated Modulation of Target Cell Properties in the Visual System @ University of Kentucky Research Foundation
A prominent feature of nervous systems is their ability to change in response to signals from the environment. This feature is even true within the brain, where the local cellular environment can determine the development and organization of several areas. It has been known for some years that activity in the visual pathways during development of many animals can affect the organization and response properties of cells in the visual system in the adult. Little is known about the mechanisms through which visual activity might modulate the properties of individual nerve cells, or neurons, in central areas. This project uses the simple model system of the optic tectum, a part of the midbrain in frogs, to see how interruption of activity in the visual pathway affects the presence and action in the tectum of two neurotransmitter chemical compounds. Electrophysiological, immunohistochemical and microscopic imaging techniques are used to assay the physiological response and neurotransmitter expression in the optic tectum, and to see whether changes are mediated by specific components of the activity of the cells that form the optic nerve from the eye to the brain. Results from this work will enhance our understanding of how environmental input shapes the properties of brain areas that receive this information. It will have an impact beyond visual neuroscience to developmental neuroscience, developmental biology, and research in fields that deal with information encoding and storage, and learning and memory.
|
0.915 |
1997 — 2000 |
Debski, Elizabeth A |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cholinergic Modulation of the Visual System
DESCRIPTION: This proposal is composed of three specific aims. The first is to determine whether the distribution and subtype composition of nicotinic and muscarinic receptors expressed by neuronal elements of Leopard frog tectum differs between mature and developing animals. This aim will employ receptor binding and immunocytochemistry in normal and surgically manipulated frogs. The second aim is to study the functional consequences of muscarinic and nicotinic receptor activation, specifically with regard to retinotectal transmission. These studies utilize patch-clamp techniques in brain slice preparations. The third aim will determine whether activation of nicotinic and muscarinic receptors is involved in the activity-dependent ordering of visual connections. These experiments involve chronically exposing a central visual target to cholinergic agonists and antagonists and then assessing the retinotopic order of its connections.
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