Area:
Ion Channel Physiology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Wenmei Shi is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2000 |
Shi, Wenmei |
F32Activity Code Description:
To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Molecular Analysis of Ih Current in the Nervous System @ California Institute of Technology
The hyperpolarization-activated cation channel called I/h is a slow inward current and permeable to both Na+ and K+. It has been found in a diverse group of cell types in various species and contributes significantly to the resting membrane potential, neuronal firing patterns, and the limitation of excessive hyperpolarization. Although well documented and important physiological functions are known for this current, many unanswered questions remain. The molecular components of these channels have been identified recently and belong to a closely related gene family called the HCN gene family. The major focus of this proposal is to understand the relationships between the identified HCN channels, possible additional subunits, and the native currents. The expression patterns of HCN channels determined by RNase protection assays and in situ hybridization will first be compared to the expression of the native current. The biophysical and pharmacological properties of homo/heteromeric HCN channels will be studied systematically using heterologous expression systems and compared to that of the native currents. The heteromerization among different HCN channels will also be investigated using coimmunopreciptation. The hypothesis that native channels requires an auxiliary subunit will be further explored. This study is essential to further investigate the mechanism generating channel diversity and to determine the contribution of this channel to physiological and pathological function.
|
1 |