Area:
Developmental Psychology, Personality Psychology, Industrial Psychology, Black Studies, Women's Studies
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High-probability grants
According to our matching algorithm, Mary McRae is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2018 — 2019 |
Mcrae, Mary Peace |
R21Activity Code Description:
To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
The Interactive Effects of Hiv and Opiates in Therapeutic Drug Penetration Into the Brain @ Virginia Commonwealth University
Despite aggressive use of combination antiretroviral (ARV) therapy, HIV infection promotes encephalitis and neurobehavioral impairment, collectively termed neuroAIDS in about half of infected individuals. Poor penetration of ARVs across the blood brain barrier likely contributes to persistence of HIV and resultant chronic brain inflammation, despite systemic effectiveness. Opiate drug abuse exacerbates cognitive impairment and pathologic CNS changes in HIV- infected persons. Yet, despite HIV and drug abuse being inextricably linked, morphine- and HIV- interactive effects on the actual penetration of therapeutic drugs (i.e., ARVs) are not well studied. Understanding how antiretroviral penetration across the BBB into CNS is altered in the setting of opioid abuse may lead to an understanding of why these patients have more severe neurocognitive impairment and may ultimately lead to the development of better therapeutic drug regimens for neuroAIDS. The long-term goal of this project is to understand the effects of opiate abuse and HIV-1 on the BBB and on antiretroviral penetration across the BBB into the brain. Approach: Using a doxycycline inducible HIV-1 Tat mouse model, the effects of morphine ± HIV-1 Tat exposure on barrier permeability and antiretroviral penetration into the brain will be assessed. Additionally, factors affecting antiretroviral tissue penetration, such as the expression and function of drug efflux proteins, will also be measured in this model. In vitro BBB studies will be performed to compliment and expand upon the in vivo studies.
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