Area:
Human neuroanatomy and development
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High-probability grants
According to our matching algorithm, Pamela Moses is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2005 — 2006 |
Moses, Pamela A |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
White Matter Diffusion Mri in Children With Early Stroke @ University of California San Diego
[unreadable] DESCRIPTION (provided by applicant): A common goal of research on various developmental brain disorders is to understand how an insult to the system affects the subsequent development of the brain. Toward this objective, we have studied cognitive and brain development in children with unilateral pre- or perinatal brain lesions (PL) for over a decade. Our longitudinal, behavioral studies have shown that children with PL have milder deficits than adult patients, and in the domain of language, the mapping between lesion site and ensuing deficits differs from adults. The mildness of children's impairments and the mismatch in functional mapping suggests an alteration in the structure and organization in the neural substrate. To examine the macroanatomic structure of the intact brain, we previously used noninvasive magnetic resonance imaging (MRI) techniques. The MRI analysis of neuroanatomical brain development revealed reduced cerebral white matter (WM) volume in both the ipsilesional and contralesional hemispheres. The WM attenuation was region-specific and occurred in sites that would typically maintain projections to or through the site of injury. Heretofore the opportunity to examine WM tracts noninyasively has been limited by standard MRI techniques. In order to examine structural changes in intact WM fiber tracts following early disruption, this study will use diffusion weighted imaging (DWI) and quantitative analysis techniques. DWI is sensitive to the movement of water molecules. In the brain, cell membranes and myelin sheaths restrict the movement of water such that molecules moves more readily parallel to axon fibers than perpendicular to them. Thus DWI methods can be used to measure water movement (diffusion) and directionality (anisotropy) as indices to assess white matter integrity. To determine the extent and degree of WM alteration following early injury, we will image the brains of 20 children with unilateral PL (11-18 years old) and 40 sex- and age-matched control children. From the DWI datasets we will derive measures of diffusivity and anisotropy in regions of previously identified WM attenuation and in the major cerebral pathways. In addition, standard MRI methods will be used to measure longitudinal relaxation time (T1) and proton density (MO) to begin to differentiate types of WM disorder that may underlie abnormal anisotropy. [unreadable] [unreadable]
|
0.958 |
2009 — 2010 |
Moses, Pamela A |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Assessment of Cognitive Neurodevelopment in Children With Cerebral Palsy in China @ San Diego State University
DESCRIPTION (provided by applicant): The goal of this planning grant is to form an interdisciplinary collaboration between scientists at the University of California, San Diego and Beijing Normal University, People's Republic of China (P.R. China) to increase the capacity for the study of neurodevelopmental disorders in P.R. China and advance the basic understanding of the effect that early neural disruption has on cognitive development in children. This grant focuses on the neurodevelopmental disorder of cerebral palsy (CP) in its most common form, spastic diplegia (SDCP). SDCP is a motor disorder of spasticity in the lower limbs that results from prenatal white matter lesions that disrupt cortical-spinal motor fibers. Since SDCP is diagnosed based on motor deficits and has been mainly studied as a motor disorder, relatively little is known about its effects on cognitive and ongoing brain development. CP is internationally prevalent and in P.R. China, which has the world's largest national population, an incident rate of 3.250 presents an urgent problem. At the same time, the scale of the population and high occurrence provides an opportunity to study SDCP as a model of neurodevelopmental pathology and to examine the effects of early and frank disruption of brain growth on cognitive outcome. The specific aims of this grant are to assist in building an infrastructure for neuropsychology and developmental cognitive neuroscience research with pediatric patient populations in P.R. China and to conduct pilot studies to demonstrate the feasibility of assessing cognitive development in children with SDCP in P.R. China. This project studies the profile of cognitive abilities, and their functional and structural neural correlates in a well defined population of children with SDCP. The study focuses on children's visuospatial abilities, shown to be compromised with SDCP, and will examine the underlying functional organization of visuospatial processes. To determine whether or not children's cognitive impairments are specific to visuospatial processing, we will also examine language performance, which has been characterized as being spared with SDCP. The examination of cognitive abilities uses a combination of standardized tests and experimental measures that are specifically designed to probe visuospatial and language abilities. The functional organization of the brain for mediation of visuospatial processes will be examined with functional magnetic resonance imaging (FMRI) and the structural integrity of connective white matter tracts will be assessed with diffusion tensor magnetic resonance imaging. The long-term goal of the project is to lay the foundation for a future R01 grant that will propose interventions that can be tested empirically and are designed to facilitate cognitive development in children with SDCP. The findings from this project will also inform our knowledge of the fundamental principles of brain development and plasticity following early insult using CP as one model of inquiry. PUBLIC HEALTH RELEVANCE: This project aims to increase our understanding of cognitive and brain development in an internationally prevalent neurodevelopmental disorder, spastic diplegia cerebral palsy. Since little is known about the cognitive impairments indicated in this motor disorder, characterizing these deficits is an important first step toward intervention. This project will also inform our knowledge of the general principles of brain development and plasticity following early insult.
|
0.938 |