Area:
Neuroscience Biology
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High-probability grants
According to our matching algorithm, Thomas J. Blanck is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1993 |
Blanck, Thomas J J |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Anesthetic Depression of the Myocardium @ Johns Hopkins University
Hypotension and cardiac arrest have been observed in patients anesthetized with the anesthetics, halothane, enflurane, and thiopental. These anesthetics are in wide clinical use today. Preliminary evidence suggests that these anesthetics might decrease the availability of Ca++ required for cardiac contraction. This project is designed to study the effect of the above mentioned anesthetics on structures in the myocardial cell that regulate Ca++ flux and control the intensity of contraction. The elements that will be studies are: the sarcolemma (SL), the outer membrane of the muscle cell; the sarcoplasmic reticulum (SR), a membranous network that controls the amount of mypolasmic Ca++; and troponin (Tn), a protein that responds to Ca++ binding by changing its shape and initiating the contractile process. Present evidence suggests that the SR is affected by anesthetics but may not be the major site of alteration of contractility. The studies outlined will examine the interaction of halothane, enflurane, and thiopental with the subcellular structures to observe alterations in Ca++ response. The results wll quantify the relative effect of each anesthetic on each structure and a possible mechanism of action will be postulated. The data obtained will help in formulating pharmacologic interventions to prevent anesthetic-induced cardiac depression in the operating room.
|
0.954 |
1985 — 1986 |
Blanck, Thomas J J |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Electrophoresis of Human Malignant Hyperthermic Muscle @ Johns Hopkins University
Malignant hyperthermia (MH) is a pharmacogenetic disorder provoked by volatile anesthetics and non-depolarizing muscle relaxants. Its incidence is between 1 in 15,000 and 1 in 50,000 anesthetics with a mortality of approximately 30%. The MH syndrome is characterized by metabolic acidosis, tachycardia, muscle rigidity and markedly elevated temperature. The preoperative diagnosis of MH is difficult because it requires a large muscle biopsy, a laboratory and physiologist dedicated to MH diagnostic studies. Those individuals with a previous family history can be screened for MH by muscle biopsy but the available tests of the muscle also carry a fair degree of uncertainty. This proposal is intended to extend our previous observations that novel low molecular weight proteins are present in MH muscle. We intend to obtain a greater number of muscle specimens from patients who have had verified MH episodes. The muscle proteins will be electrophoresed and the extra proteins isolated and characterized. The extra MH proteins will be quantitated by densitometric scans of the electrophoretic gels and a correlation between MH susceptibility and the amount of extra MH proteins made.
|
0.954 |