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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Xiaoke Chen is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 2017 — 2018 | Chen, Xiaoke | R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Imaging the Temperature Sensing Circuits in the Spinal Cord @ Stanford University Abstract: Spinal cord is the initial stage along the thermosensory pathway that integrates and processes temperature information from the peripheral thermosensory neurons. After tissue and nerve injury, there are significant changes at the level of the spinal cord and these maladaptive events often result in thermal allodynia (innocuous temperature perceived as painful) and hyperalgesia (normal noxious temperature elicit pain of greater intensity). The heterogeneity of the neurochemical organization of the dorsal spinal cord pose a major challenge for studying spinal cord circuitry and its changes in pain condition. Understanding the roles of distinct cell types hold the key to deciphering the neural circuits in the dorsal horn. Here, we propose to make use of a newly developed in vivo spinal cord imaging platform, a precisely controlled temperature stimulus system, and transgenic mouse lines to dissect the role of each cell type in processing temperature information in the spinal cord. In this proposal, we focus on spinal inhibitory interneurons as they are important for gating the transmission of pain information to the brain, and loss of inhibition has been proposed as a general mechanism for thermal hypersensitivity after tissue and nerve injury. In aim1, we will image thermosensory responses in different types of inhibitory interneurons, and examine the impact of silencing their activities on the sensory response in the rest of the circuitry. In aim2, we will perform the similar experiments in animal models of inflammatory pain to determine the changes in thermosensory responses of each type of inhibitory interneurons and their effect on other spinal neurons during inflammatory pain. The results from proposed work will not only provide basic knowledge on neurobiology of thermosensation, but also potentially generate insights useful for treating pain. |
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| 2018 — 2021 | Chen, Xiaoke | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. R56Activity Code Description: To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. This grant will underwrite highly meritorious applications that if given the opportunity to revise their application could meet IC recommended standards and would be missed opportunities if not funded. Interim funded ends when the applicant succeeds in obtaining an R01 or other competing award built on the R56 grant. These awards are not renewable. |
Thalamic Circuits For Prosocial Behaviors in Mice @ Stanford University Abstract Social interactions are essential for human health and society. However, the neural circuitry basis for many social behaviors remains uncertain. Beside classical behaviors such as aggression, pair bonding and parenting, recent research has demonstrated that rodents are also capable of behaviors to comfort distressed individuals. To study the neural basis of these prosocial behaviors, we recently adapted a protocol that produces consolation- like behavior in socially monogamous prairie voles to the widely used C57BL/6J mice. Our preliminary experiments indicate an important role for the paraventricular nucleus of the thalamus (PVT) in controlling consolation-like behavior in mice. Comforting a distressed cagemate elicited robust c-Fos expression in the PVT and pharmacogenetic silencing of the PVT dramatically reduced consolation-like behavior. Based on these intriguing results, we propose to (Aim1) perform in vivo electrophysiology recording and optogenetic manipulation of PVT to determine the role of PVT during consolation-like behavior. In comforting mice, there was also strong activation of the prefrontal cortex and ventral subiculum which are major inputs to the PVT. We therefore propose to (Aim2) identify the inputs responsible for PVT activity during prosocial behavior and expand our understanding of the circuitry using viral tracing. The proposed studies defining the prosocial neural circuitry will add to the knowledge base necessary for treating conditions with social deficits. |
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| 2019 — 2021 | Chen, Xiaoke | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Thalamic Circuits Underlying Opioid Seeking @ Stanford University Prescription opioid abuse is the fastest growing drug problem in the United States. Now, deaths from overdose of opioid pain relievers exceed those from all illegal drugs. Chronic opioid use induces opioid dependence, which is characterized by extremely unpleasant physiological and psychological symptoms after drug use is terminated. Opioid users learn to associate opioid intake with relief from negative physical and affective states. This maladaptive association might last long after withdrawal has terminated and underlie the drug cravings experience by many users after exposure to drug-associated cues or stressful life events. We have recently identified that the paraventricular nucleus of the thalamus (PVT) is a prominent neuronal substrate mediating the physical signs and negative emotion accompanied with opioid withdrawal, which provide a unique opportunity to directly examine the contribution of withdrawal states to opioid-associated memories. In this application, we propose to use pathway specific optogenetic and pharmacogenetic manipulation (1) to determining roles of the PVT output pathways in the formation and maintenance of opioid-associated memories;? (2) to study morphine induced plasticity in each PVT pathway and impact of pathway silencing on this plasticity;? (3) we will combine pathway specific manipulation in the PVT, c-Fos iDISCO+, and light sheet fluorescent microscopy to mapping brain-wide network activities underlying opioid-associated memories. Our work will inspire the development of novel strategy to treat opioid abuse. |
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