Area:
General, Pharmacology, Animal Physiology Biology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Steven H. Platts is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2002 — 2003 |
Platts, Steven H |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Modulation of the Endothelial Glycocalyx by Adenosine @ University of Virginia Charlottesville
In this application, the applicant proposes to study the effects of adenosine and other vasoactive compounds on the capillary endothelial glycocalyx. Recent work has shown the glycocalyx to be a thick layer of proteoglycans and glycoproteins that lines the endothelial vascular space and appears to be the true interface between the blood and the vascular cells. The layer has been proposed to play a role in vascular permeability, hemostasis and capillary tube hematocrit. Previous work in this lab showed that TNF-alpha (known to be released from mast cells) causes increased glycocalyx permeability. We hypothesize that adenosine will increase the permeability of FITC-dextran 70 into the glycocalyx, through degranulation of mast cells via the A3 adenosine receptors. The goals of this work are to elucidate the effects of varying doses of adenosine receptor. The goals of this work are to elucidate the effects of varying doses of adenosine (and other vasodilators) on glycocalyx permeability and thickness, compare this effect to that elicited by other vasoactive agents which act either through mast cells or independent of mast cells, and evaluate the role of the A3 adenosine receptor in this response using A3 knockout mice as well as other state of the art techniques. We believe and the endothelial glycocalyx will provide to be an important regulator of many vascular processes.
|
0.951 |