Area:
development, interneurons, psychiatric illness
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Edmund Au is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2019 — 2020 |
Au, Edmund |
R03Activity Code Description:
To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Developing a Stem Cell-Based Model to Study Mge and Cge Interneuron Lineage Specification @ Columbia University Health Sciences
Cortical interneurons are a diverse inhibitory neuron population in the cortex whose dysfunction is strongly linked with neuropsychiatric illness. How diversity comes about in interneurons is a poorly understood process. Elucidating molecular and transcriptional mechanisms governing interneuron diversity would greatly facilitate our understanding of how interneurons contribute to disease. It would also facilitate efforts to model neuropsychiatric disease with human stem cell-derived neurons and help to uncover novel therapeutic avenues. Current tools to study the molecular mechanisms driving interneuron diversity are limited in two important aspects: 1) sample material is limited because the embryonic progenitor domains for interneurons are small and not well-suited to applications such as biochemistry, screening and ChIP sequencing; 2) manipulating conditions by mouse genetics is relatively low- throughput. Objective: We therefore propose to develop a stem cell differentiation-based model of interneuron development. Approach: It is based on an existing system that we developed earlier but will now 1) encompass the entire interneuron lineage and has the capacity to differentially label MGE and CGE lineages. As an initial assay to test the validity of our new model, we will 2) examine the effects of transcriptionally-specifying both MGE and CGE lineages with a newly-identified Wnt-Ryk signaling pathway. We recently found that Wnt- Ryk regulates MGE interneuron identity, and this study will examine its potential role in regulating CGE identity. Interneurons generated from this new model will be assay by in vitro differentiation as well as by 3) in utero transplantation, which will stringently assay their capacity to engraft, migrated and integrate with host circuitry. The proposed experiments will allow us to definitively characterize our new in vitro model, opening the way to more expansive studies in which a stem cell-based model serves as a powerful platform to identify molecular and genetic pathways that govern cortical interneuron lineage specification.
|
1 |