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High-probability grants
According to our matching algorithm, Jessica H. Brann is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2003 — 2005 |
Brann, Jessica H |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Signal Transduction in the Vomeronasal Organ @ Florida State University
The vomeronasal organ (VNO) is the receptor portion of a distinct olfactory system found in most vertebrates that detects socially relevant chemical cues. While the mechanism of signal transduction in the main olfactory system has been well described, less is known about the vomeronasal system. It is thought that chemical communication is transduced when a ligand (chemical or pheromone) binds to a G-protein coupled receptor (GPCR) in the plasma membrane of a vomeronasal sensory neuron (VSN). The GPCRs are located on the microvilli of VSNs, where other signaling components are located. The transduction event(s) between ligand binding and the final electrical event via any of these signaling elements has not been shown. This proposal seeks to investigate downstream signaling events leading to an electrical conductance in response to a species-specific chemical. More specifically, this proposal investigates the role of the nonspecific cation transient receptor potential (TRPC) channels and inositol 1,4,5-trisphosphate receptors in the odor response by electrophysiological and pharmacological approaches. In addition, I will examine the role of the protein-protein interaction between the two types of ion channels in the propagation of the odor response.
|
0.942 |
2006 — 2008 |
Brann, Jessica H |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Lifelong Development of the Vomeronasal Epithelium @ Columbia Univ New York Morningside
[unreadable] DESCRIPTION (provided by applicant): The olfactory system, including the main and accessory (vomeronasal) systems, is a component of the central nervous system known to proliferate throughout the life of the animal. The mouse vomeronasal epithelium detects odorants indicative of reproductive and social status. This detection occurs by a family of vomeronasal receptor (VR) genes which are G protein-coupled receptors (GPCRs). It is not known how the expression of these VR genes, and other genes across the whole genome, changes as the animal progresses from an early postnatal stage to aged adulthood. In addition, it is not known if the regenerative potential of the vomeronasal epithelium is altered as the animal ages. In the current proposal, I will use a custom microarray to examine how vomeronasal receptor gene expression changes in the vomeronasal epithelium over the lifespan of the mouse. I will also utilize a commercial Affymetrix array to monitor 37,000 other genes over the same time period with the goal of identifying those genes involved in the process of aging in the vomeronasal system. In addition, I will investigate whether the rates of proliferation and apoptosis are altered in the vomeronasal epithelium over all developmental stages. Finally, I will examine whether the vomeronasal epithelium regenerates with the same efficacy throughout the lifespan of the animal. This proposal seeks to identify those genes involved in the development and aging of a sensory tissue across the lifespan of the mouse. In addition, it will examine how this unique tissue renews itself over the course of that lifespan. These important experiments will inform us on how a tissue undergoes the process of aging, and possibly provide insights into how a tissue capable of reconstitution accomplishes this difficult process. [unreadable] [unreadable] [unreadable]
|
0.906 |