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High-probability grants
According to our matching algorithm, Charles J. Hodge is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1987 — 1989 |
Hodge, Charles J Jr |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
The Dorsolateral Spinothalamic Tract @ Upstate Medical University
The goal is to gain further understanding of the spinothalamic tract, one of the principle pathways conveying information about painful stimuli to the brain. The cells of origin and thalamic terminations of the dorsal spinothalamic tract (DSTT), which travels in the dorsolateral quadrant of the spinal cord, will be determined in monkeys and cats, and compared to the origins and terminations of the classical ventral spinothalamic tract (VSTT), which travels in the ventrolateral quadrant of the spinal cord. Retrograde and anterograde transport of horseradish peroxidase and flourescent tracers will be used to anatomically map the locations of the cells of origin and terminations of these two separate pathways. In addition, recordings will be made from the lateral sensory thalamus in anesthetized cats and monkeys, and the relative contributions of the VSTT and the DSTT to the responses of these units elicited by cutaneous stimulation will be determined by transiently blocking transmission through either the dorsolateral or the ventrolateral quadrant of the spinal cord. The DSTT has only recently been discovered and is likely one of the major nociceptive specific inputs to the thalamus. Consequently gaining a better understanding of this system will allow new insights into the processing of painful stimuli. The adequate treatment of both acute and chronic pain states in humans clearly depends on indepth knowledge about the pathways that carry information concerning peripheral painful stimuli from the spinal cord to the thalamus.
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1 |
2003 — 2006 |
Hodge, Charles J |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cortical Plasticity: Mechanisms and Modulation @ Upstate Medical University
DESCRIPTION (provided by applicant): Stroke and traumatic brain injury afflict more than 600,000 Americans annually, resulting in some level of functional impairment. While stroke afflicts primarily an adult population, traumatic brain injury affects mostly children and young adults. Variable recovery of function and some dysfunction will occur in most patients due to the innate ability of the nervous system to reorganize. This process is known as plasticity. Recent studies demonstrate a dramatic improvement in the speed and extent of behavioral recovery after brain injury by the use of the neurostimulant amphetamine. In contrast, phenytoin, a commonly administered antiseizure medication, retards recovery. Although the effects of these drugs have been demonstrated on behavioral recovery in both animal models and humans, their influence on mechanisms of plasticity remains largely unknown. The purpose of this project is to determine mechanisms that govern plasticity in a well-characterized rat model of cortical injury that results in a well-defined plastic response observed through functional optical imaging techniques. We propose to: * Evaluate the modulation by d-amphetamine (stimulant) and phenytoin (depressant) on functional cortical reorganization in the rat whisker/barrel cortex following a focal excitotoxic injury, utilizing intrinsic optical imaging. * Examine changes in gene expression that are associated with plasticity using "gene chip" techniques in individual affected and spared cortical barrels to decipher the genetic response underlying observed functional outcomes and to gain insight into mechanisms by which d-amphetamine alters recovery following injury. * Determine whether structural alterations in the intra-cortical or thalamocortical connectivity correspond to observed functional changes using neural pathway tracing techniques. Functional imaging techniques allow us to determine the extent and time course of plastic changes in a longitudinal fashion. Our studies will elaborate critical aspects of cortical plasticity in terms of underlying gene expression, structural and functional reorganization following focal cortical injury. The determined responses will be modulated by pharmacologic agents in common clinical usage. The insight gained from these studies will help determine most effective management of patients to maximize recovery from brain injury.
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