Edward B. Pivorun - US grants
Affiliations: | Zoology | Clemson University, Clemson, SC, United States |
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Edward B. Pivorun is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
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| 1986 | Pivorun, Edward B | R15Activity Code Description: Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Endogenous Opiate and Monoamine Modulation of Torpor @ Clemson University A paucity of information exists on the physiology and endocrinology of daily torpor. This thermoregulatory response may represent a physiological state intermediate between sleep and hibernation. A understanding of the physiological and endocrinological basis for daily torpor may lead to a better understanding of sleep and the mechanisms that enable the gradual, controlled entry of mammals into hibernation. This proposal seeks to characterize via computerized radiotelemetry the induced (food rationed) torpor patterns displayed by Peromyscus maniculatus, the deermouse. The proposal also seeks to determine the role that the endogenous opiates, in particualr B-endorphin (BE), play in modulating stress induced torpor. Information on the opiates will be obtained through IP administration of naloxone and through intraventricular administration of BE during different stages of the torpor/awake cycle. The role of the monoamines in modulating torpor will be determined through the use of specific monoamine agonists and antagonists. HPLC analyses of hypothalamic monoamine concentrations will be used to characterize the temporal dynamics and functional relationships of the metabolism of these monoamines with respect to torpor. The role of the suprachiasmatic nucleus (SCN) in the regulation of the timing of daily torpor will also be determined through the use of lesions and blockage of monoamine metabolism in the SCN. |
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| 1988 — 1991 | Pivorun, Edward | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Computer Interfacing to Bioinstrumentation @ Clemson University The funds from this award will provide the biological sciences at Clemson University with the instrumentation necessary to instruct students in 1) the techniques utilized for interfacing instruments with microcomputer and 2) systems for the monitoring for biological data. The grant will supply funds for the purchase of 10 computers, 10 A/D interfacing boards with software, 10 amplifiers and the various transducers needed to transport biological information to the amplifier and computer. Funds will also be used for procurement of electronics and transducer components for configuration of student stations that will allow for the direct "hands on" experience in the understanding of the basic electronics associated with transducer interfacing to biological systems. An extensive "hands on" approach to the use of bioinstrumentation will be available to the students with theory behind the instruments and their limitations stressed in the lectures and the laboratory of a bioinstrumentation course. The students will be exposed to the basis electronics and limitations of transducers, amplifiers and input circuits to the microcomputer. In addition to providing the students with the circuits, amplifiers and transducers needed for the configuration of computerized physiology monitoring systems in this course, students will have these monitoring stations available in the various physiology courses. Portions of the lab exercises from the bioinstrumentation course will also be utilized in the physiology labs to provide the student with a working knowledge of the basics of transducers, amplifiers nd computer interfacing hardware. The grantee institution is matching this NSF award with funds from non-Federal sources. |
0.915 |
| 1992 — 1996 | Pivorun, Edward Kosinski, Robert Dickey, Jean |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Introducing Microcomputer-Based Laboratories Into An Investigative Introductory Biology Course @ Clemson University The investigators address three major national needs for non- majors courses oriented to physiology and anatomy: 1) well designed modules to serve classes based on investigative laboratories, 2) a means to decrease reliance on experimental use of vertebrates, and 3) a means to decrease the cost of laboratory equipment so all students can have some hands-on experience. The proposal requests funds to design and implement a set of microcomputer-based laboratories (MBL) that will: 1) allow measurement of basic physiologic processes, 2) facilitate direct interface of the data with microcomputers, and 3) enable students to easily record, graph and present results. The MBL modules will cover 3 basic systems; sensory (how to measure skin temperature, response time and heat flux), effector (how to measure reflex arcs, performance and rates of fatigue) and cardiopulmonary (measure heart and respiration rate). The expected outcomes are: 1) an investigative laboratory based second semester non-majors biology course, and 2) a text describing how to build similar inexpensive equipment so that the MBL can be implemented at other institutions. |
0.915 |
| 1996 | Pivorun, Edward B | R15Activity Code Description: Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Ap4a Modulation Pc12 Cell Monoamine Oxidase Activity @ Clemson University DESCRIPTION: (from Abstract) Most studies dealing with monoamine oxidase (MAO) have emphasized the development of inhibitors of this enzyme for controlling neurotransmitter metabolism in patients with diseases such as Parkinson's. The literature is replete with information on natural and man-made inhibitors of MAO activity. However, there is virtually no information on modulators of MAO that result in enhanced activity of this enzyme. The applicants' laboratory has recently demonstrated that diadenosine tetraphosphate, Ap4A, may be one, of only a few, endogenous extracellular stimulatory agents of MAO activity. They have undertaken a series of experiments aimed at understanding the signal transduction pathway associated with Ap4A receptor binding and the enhanced activation of MAO. An understanding of the transduction pathway(s) involved with Ap4A receptor activation may result in a better understanding of the signal transduction events associated with MAO activation. In addition, if the Ap4A activated transduction pathway(s) is a novel activation pathway(s) for MAO, knowledge of this pathway(s) may allow for the development of a new class of agonists, antagonists or pharmacological agents for controlling MAO activity. Abnormal or elevated level of Ap4A in the CNS and adrenal gland may lead to pathogenic conditions associated with depleted catecholamine stores, such as Parkinson's Disease. The potential importance of MAO in the catabolism of various xenobiotics suggests that Ap4A may have an important therapeutic role. The specific aims of this proposal are: (A) To determine the dosage effects of the extracellular diadenosine polyphosphates on MAO activity in PC12 cells and brain synaptosomes obtained form the caudate putamen of rat brains. Dopamine metabolites will be measured by using 1) HPLC with electrochemical detection and 2) radiochemical analyses. The temporal dynamics of the application of Ap4A will be determined to assess the effects of short term and chronic exposure of the cells and synaptosomes; (B) To determine the effects of extracellular Ap4A on adenylate cyclase activity and cAMP levels in PC12 cells. cAMP levels will be assayed by an enzyme linked immunoassay; adenylate cyclase activity will be determined using [a32P] ATP and chromatography; (C) To determine the role of G protein involvement in the Ap4A elicited response by measuring GTPase enzymatic activity; (D) To determine the involvement of tyrosine kinases and tyrosine phosphatases in the Ap4A initiated signal transduction pathway. SDS-PAGE and [32P]phosphate will be used to label cells and determine the extent of phosphorylation or dephosphorylation of specific proteins. (E) To determine the effects of Ap4A delivery to the caudate putamen of the conscious rat with in vivo microdialysis in conjunction with HPLC. |
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