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High-probability grants
According to our matching algorithm, Deepak Pandya is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1993 |
Pandya, Deepak N |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Organization of the Cerebral Cortex @ Boston University Medical Campus
The long-term objective of this research program is to understand the structural and functional organization of the cerebral cortex. Our ongoing investigations have addressed this issue by investigating intrinsic connections and cortical architecture in the sensory and limbic regions of the primate cortex. From the results of these studies in the auditory cortices of the superior temporal region we have drived several organizational principles of cortical connectivity. Chief among these is the principle that a progressive architectonic elaboration of cortical areas is accompanied by an orderly pattern of local cortical connections including their specific laminar origin and termination. Our proposed investigations will test the applicability of these principles in other cortical regions as well as to subcortical connectivity. These investigations will be focused in the cortex of the superior temporal region, the posterior parahippocampal gyrus, and the posterior cingulate cortex and will utilize light microscopic axonal tracing techniques, including radioactively labeled amino acids, fluorescent retrograde tracers and horseradish peroxidase. The data will be analyzed to elucidate both intrinsic cortical connectivity as well as specific thalamocortical connections and connections of the posterior cingulate and parahippocampal cortices with the caudally adjacent visual cortex. We will also investigate the ultrastructural characteristics of afferent termination in the auditory cortex, utilizing the Golgi-EM and HRP-EM procedures in combination with lesion-induced degeneration to characterize afferent termination on identified local circuit and projection neurons. In the cingulate cortex we will localize both opiate and muscarinic acetylcholine receptor complexes utilizing in vitro receptor binding techniques combined with lesions in the thalamus to investigate the association of these receptors with thalamocortical afferents. Finally, in the posterior parahippocampal gyrus, on the basis of some of the known cortical connections of this area, we will utilize the ablation behavior method to investigate the role of this area in visuospatial learning and memory. The application of these different methods of analysis to the primate cerebral cortex are aimed at acquiring sufficient insight into the connections, function, synaptic and transmitter specific receptor characteristics that may ultimately aid in the understanding and treatment of neurological disease.
|
0.958 |
1987 — 1988 |
Pandya, Deepak N |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Organization of the Cere4bral Cortex @ Boston University Medical Campus
The objective of this research program is to understand the structural and functional significance of the cerebral cortex. Our previous research has focused upon the long cortical connections that link sensory, association and limbic cortical areas. These studies have revealed underlying principles of the organization of cortical connections. Our recent investigations have focused on the intrinsic connectivity and cytoarchitecture of the auditory cortices and have revealed that the intrinsic connections of the auditory areas are organized according to a set of principles that appears linked to the cytoarchitectonic subdivision of these areas. This organizational pattern is also reflected in the thalamocortical connections of each subdivision. Additional studies have suggested that similar organizational principles may govern the local connectivity of the inferotemporal and posterior parahippocampal areas of the ventral temporal lobe, regions that may constitute parallel streams for the outflow of visual information from the occipital lobe. The visual input to the inferotemporal cortex appears to originate primarily in areas where the central part of the visual field is represented while input to the posterior parahippocampal gyrus originates in areas where the peripheral part of the visual field is represented. This suggests that these two areas may constitute two distinct visual pathways through the temporal lobe. Our proposed studies are designed to examine this hypothesis by investigating the connections of the occipital cortices leading to both the inferotemporal and posterior parahippocampal areas. We also propose to investigate the differential thalamocortical and corticothalamic connectivity of each stage along these parallel pathways. Additionally, in the posterior parahippocampal gyrus we will determine the relationship of these visual and thalamic afferents to afferents from the parietal, superior temporal, frontal and limbic cortices. Finally, we will investigate the efferent outflow from these various architectonic subdivisions of the inferotemporal and posterior parahippocampal areas into the limbic system of the medial temporal lobe: the entorhinal areas, the hippocampal formation and the amygdala. These studies will be conducted in the rhesus monkey using complementary anterograde and retrograde tracing techniques.
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0.958 |