John Bender - US grants

Affiliations:

Case Western Reserve University, Cleveland Heights, OH, United States

Area:

neuroethology

Website:

http://www.its.caltech.edu/~jbender

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High-probability grants

According to our matching algorithm, John Bender is the likely recipient of the following grants.

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Years	Recipients	Code	Title / Keywords	Matching score
1984 — 1986	Bender, John	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Petrogenetic Study of Basalts From Ridge/Transform Inter- Sections @ University of North Carolina At Charlotte	0.925
1985 — 1987	Bender, John	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Geochemical and Petrologic Effects of Transform Faults: East Pacific Rise @ University of North Carolina At Charlotte	0.925
1987 — 1989	Bender, John	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Petrogenetic Studies of East Pacific Rise Basalts @ University of North Carolina At Charlotte	0.925
1989 — 1991	Bender, John	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Rui: High Resolution Investigation of Small Offsets Along the East Pacific Rise @ University of North Carolina At Charlotte This is a project to clarify the importance of small scale ridge offsets with regard to magmatic segmentation. The field program will use transponder navigated, closely spaced dredging, together with SeaBeam, and camera tows to study the area from 12 to 12 30' N along the East Pacific Rise where preliminary data shows the existence of magmatic segmentation. The new field data will be integrated with existing SeaMARC I data to get fine scale resolution of along-axis variations in chemistry to determine the scale of magmatic segmentation. The project will also involve off-axis dredges that, coupled with side scan and camera data, will help resolve temporal variations as well. %%% Suggested scales of volcanic centers on the East Pacific Rise range from a few kilometers to a few hundred kilometers. Thus the appropriate scale on which to consider the magmatic organization of the East Pacific Rise is uncertain. This project will take an important step in clarifying the scale of magmatic segmentation and its relation to small ridge offsets. This is a problem of first order importance in marine basalt petrogenesis. Show summary Hide summary	0.925
1991 — 1993	Bender, John	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Petrological Investigations of Closely Spaced Samples From the Epr: Spatial and Temporal Systematics @ University of North Carolina At Chapel Hill In October 1989, the principal investigators began a study of the extent to which Devals bound discrete magmatic and tectonic units of the East Pacific Rise. They used a 'rock coring' sampling technique, as well as dredging and a new precussion core rock sampler to collect samples at 198 sites. Bottom photographs and videos were also obtained. The result is an unprecedented data set that includes very precisely located samples, both along and across the East Pacific Rise, over nearly fifty kilometers of ridge. Show summary Hide summary	0.924
1998 — 1999	Bender, John	F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas.	Total Synthesis of the Rft Inhibitor Cp225917 @ University of Texas Austin The long term objective of the proposed research is to provide the first nonracemic, efficient, total synthesis of CP-225,917. This molecule was recently isolated from the culture broth of an unidentified fungus, and was shown to inhibit the enzymes ras farnesyl transferase (RFT) and squalene synthase (SQS). As the farnesylation of ras protein is an initial step in cell division, inhibition of RFT could provide a useful chemotherapeutic process for controlling cancer growth initiated by ras gene mutations. Also, as SQS has been shown to be involved in the first committed step of cholesterol biosynthesis, its inhibition could control cholesterol levels in the body. The proposal outlines a 20 step process for the synthesis of this complex molecule from available starting materials. The key transformations involve an intramolcular [2+2]- cycloaddition forming a cyclobutene intermediate, and a novel anionic cascade process initiated by a known Michael addition forming the required bicyclo[4.3.1]deca-1(9),4-diene. This cascade will be independently explored in a model study before the total synthesis is attempted. Also, multiple contigency plans for dealing with undesired alternative reaction pathways are discussed. The convergent nature and the flexibility of the proposed total synthesis should allow for the preparation of various analogues for further biological testing. Show summary Hide summary	0.94
2001 — 2004	Bender, John Smart, Robert Matchett, Stephen	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Ft-Nmr: Hands-On Access in the Undergraduate Curriculum @ Grand Valley State University Chemistry (12) The importance of Fourier Transform-Nuclear Magnetic Resonance (FT-NMR) spectroscopy in modern chemistry is reflected in the 1999 American Chemical Society Committee on Professional Training guidelines for the undergraduate organic chemistry curriculum which recommends hands-on training in 1 H and 13 C NMR for undergraduate students. In addition, more advanced pulse sequences such as 2-D NMR have become increasingly vital tools for the modern chemist. In order to incorporate these recommendations, the Department of Chemistry has purchased a 300 MHz instrument capable of teaching the broad range of experiments that comprise modern FT-NMR. We are infusing this technology across our undergraduate curriculum in a series of experiments, adapted from the current literature (research and educational), that is designed to progressively introduce a series of 1-D and 2-D NMR techniques. In doing so, we are adapting the approach recently instituted at Florida State University (CCLI A&I DUE-9972198), adjusting for the size of our student population and tuned to existing strengths in our curriculum. The instrument is being used first by students in their sophomore-level Organic Chemistry sequence to interpret and to obtain 1 H and 13 C spectra, then in a progressive fashion in Qualitative Organic Analysis, Physical Chemistry, Advanced Synthetic Methods, and Undergraduate Research in which more sophisticated techniques and the multi-nuclear nature of FT-NMR are explored. Outcomes include students with extensive hands-on experience in a variety of NMR techniques. Additionally, we are studying the pedagogy of teaching NMR across the curriculum and are in the process of producing a web accessible database of spectral FID's emphasizing 2-D NMR as a problem-solving tool. The database is providing a unique resource to other universities that may wish to implement 2-D NMR spectroscopy into their curriculum but that lack the instrumental capabilities to do so. Show summary Hide summary	0.936
2017 — 2020	Neils, Thomas Bender, John Biros, Shannon Ngassa, Felix Leonard, David	N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information	Acquisition of a 400 Mhz Nmr For Research and Training At Grand Valley State University, Grand Rapids Community College and Aquinas College @ Grand Valley State University This award is supported by the Major Research Instrumentation Program (MRI) and the Chemistry Research Instrumentation Program. With it, Professor Shannon Biros from Grand Valley State University and colleagues have acquired a 400 MHz nuclear magnetic resonance (NMR) spectrometer. An NMR spectrometer enables the identification of the atoms (for example, hydrogen, carbon, etc.) in the material. This analytic technique is used to identify chemicals, drugs, proteins or unknown substances. The spectrometer is housed at Grand Valley State University (GVSU) and used by their faculty and students, as well as faculty and students at Grand Rapids Community College (GRCC) and Aquinas College. The instrument advances research on metals important for potential uses in optical materials and biosensors, on protein binding to antibiotic substances and on new materials with applications such as photovoltaics and solar cells. Many students at GVSU and GRCC (40-60%) are the first in their family to attend college. The exposure of these students to cutting edge instrumentation facilitates their development as scientifically literate individuals and contributes to a competitive scientific workforce. The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts investigations of selective f-element extraction agents; studies of bond fission regioselectivity in nucleophilic aromatic substitution of arylsulfonates, the preparations of main group derivatives, and d,f-block metallation of mono- and diphosphines. The instrument also serves researchers investigating the structure lactamase enzymes and studying the relationship between ligand/additive structure and reactivity. Show summary Hide summary	0.936