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High-probability grants
According to our matching algorithm, Mark A. Stopfer is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1996 — 1999 |
Stopfer, Mark A |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Olfactory Information Coding @ California Institute of Technology
An important goal of neuroscience is to understand the neural mechanisms by which organisms detect and represent sensory experiences. There is compelling evidence that the mushroom bodies of the insect brain participate significantly in olfactory and memory functions. These structures, in important ways, resemble mammalian brain areas believed to perform similar functions. The mushroom bodies thus serve as a relatively simple model for olfactory and memory processing with odorant serving as a natural, behaviorally relevant form of sensory stimulation. In the locust mushroom bodies, as in mammalian pyriform cortex, odors induce synchronous neuronal activity detectable as tightly coordinated activity among individual neurons, and as oscillating local field potentials. This synchronous activity changes as the animal acquires experience with a given odorant. The goal of the current project is to investigate how this neural synchrony is generated, what functions it might subserve, and where some forms of synaptic plasticity may reside in this system. These studies will employ extracellular and intracellular recording techniques to examine the contributions of specific classes of interneurons to the odor-induced oscillations in the presence of both novel and familiar odorants. The analysis will likely reveal general features of coordinated neuron assemblies involved in sensory processing and memory.
|
0.94 |
2005 — 2018 |
Stopfer, Mark A |
Z01Activity Code Description: Undocumented code - click on the grant title for more information. ZIAActivity Code Description: Undocumented code - click on the grant title for more information. |
Sensory Coding by Ensembles of Neurons. @ Child Health and Human Development
An important function of the nervous system is to transform information about the environment into a succession of neural codes that the brain can process into memories and behaviors. Odors are detected by a large assortment of receptor neurons, each with different sensitivities. These neurons respond to odors by firing simple patterns of action potentials that are conveyed to a brain structure called the olfactory bulb (in vertebrates) or the antennal lobe (in insects). There, interactions between excitatory and inhibitory neurons broadly distribute olfactory information across large populations of cells, add to the complexity of the firing patterns with sequences of excitation and inhibition, and synchronize responsive cells into oscillatory waves of spiking. This information is then sent to deeper brain areas including the piriform cortex (in vertebrates) or the mushroom body (in insects), where the broadly distributed, synchronized input is transformed into sparse patterns of spiking distributed across huge numbers of neurons, a format ideal for comparison and memorization. Less is known about gustatory coding; analyses of this process have been fraught with disagreement and controversy. Our lab investigates both odor and taste coding in parallel with similar methods, focusing on relatively simple species in which experiments can be performed in intact, awake animals, and neural circuits can be traced from point to point from the periphery to the brain. Our recent results show the gustatory system is organized and functions very much like the olfactory system. We are pursuing this analysis with the goal of understanding how the nervous system processes essential and complex forms of information.
|
0.912 |