Charles Anderson, Ph.D. - US grants
Affiliations: | Computer Science | Colorado State University, Fort Collins, CO |
Website:
https://www.cs.colostate.edu/~anderson/wp/We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Charles Anderson is the likely recipient of the following grants.Years | Recipients | Code | Title / Keywords | Matching score |
---|---|---|---|---|
1975 — 1977 | Anderson, Charles Schlesinger, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Numerical Simulation of Severe Convective Storms @ University of Wisconsin-Madison |
0.936 |
1975 — 1977 | Barchet, W.richard Anderson, Charles Schlesinger, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ University of Wisconsin-Madison |
0.936 |
1977 — 1979 | Anderson, Charles Schlesinger, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Analysis of Severe Storm Dynamics and Energetics Using a Three-Dimensional Numerical Simulation @ University of Wisconsin-Madison |
0.936 |
1977 — 1980 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
1976 Postdoctoral Energy-Related Fellowship Program @ Individual Award |
0.901 |
1979 — 1980 | Anderson, Charles Schlesinger, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Cooperative Studies in Severe Storms Using Three-Dimensionalnumerical Simulations @ University of Wisconsin-Madison |
0.936 |
1981 — 1983 | Anderson, Charles Schlesinger, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Studies of the Development and Evolution of Local Severe Storms From Sesame 1979 Data @ University of Wisconsin-Madison |
0.936 |
1984 — 1986 | Anderson, Charles Schlesinger, Robert |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Continued Studies of Tornadic Storms During Sesame 1979 and Related Cases @ University of Wisconsin-Madison |
0.936 |
1985 — 1986 | Anderson, Charles B [⬀] | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Renal Transplant Enhancement by Donor-Specific Blood @ Washington University Successful adaptation to organ allografting occurs under a variety of poorly understood conditions. The use of donor-specific antigen, administered intravenously under immunosuppressive coverage, to induce enhancement or tolerance in a large variety of allograft models is well established. More recently, there is an awareness of the beneficial effects of random blood tranfusion prior to human renal transplantation. The purpose of this project is to confirm previous pilot studies which indicate that administration of donor-specific blood products under immunosuppressive coverage prior to human renal allografting led to no evidence of sensitization and no immunologic graft loss in the postoperate period. One haplotype living-donor renal transplants, will be performed after a six to eight week course of oral azathioprine during which time the recipient will have received 600 ml of donor-specific blood in three aliquots. Immunologic monitoring will include: T- and B-cell crossmatches with temperature variants, ADCC crossmatch, direct CML, one-way MLC (cellular responsiveness), one-way MLC (indirect assay for serum blocking factors), li titer, heterophile titer, T- and B-cell autoantibody with temperature variants and monoclonal antibody characterization of T-cells. Testing will be performed before, and after transfusion and in the postrenal tranplantation period. Posternal transplantation immunosuppression will include azathioprine and prednisone. Randomized control groups will include: (1) neither intentional preoperative blood nor azathioprine treatment, and (2) azathioprine and non-donar-specific blood. Sensitization in the form of donor-specific warm T-cell lymphocytoxic antibody development will preclude transplantation. Results in the experimental and control groups will be analyzed with regard to: (1) allograft survival (absence of immunologic graft failure) at six months as a prediction of long-term function; (2) immunologic monitoring changes and the development of sensitization (warm donor-specific T-cell antibody) during the pretransplantation phase; and (3) during the postransplantation phase. A statistically significant improvement in allograft survival from donor-specific as opposed to non-donor-specific or no blood transfusions may eventually permit the use of related kidney donors with less than one haplotype match thus enlarging the potential pool of donors. |
0.905 |
1985 — 1990 | Anderson, Charles B [⬀] | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Prostaglandins and Renal Allograft Rejection @ Washington University Renal allografts undergoing rejection metabolize arachidonic acid (AA) to a variety of cyclooxygenase and lipoxygenase products and these eicosanoids possess powerful effects on the immune system and renal function. This proposal investigates the role of altered eicosanoid production on renal allograft function and immunologic reactions occurring in the allograft. Also, the metabolism of AA by kidneys subjected to ischemia-reperfusion injury and toxic doses of cyclosporine A (CYS) will be determined and correlated with renal function. A standard dog renal allograft model will be used to study renal allograft function during pharmacologic intervention of AA metabolism. Renal allograft function will be assessed by daily measurements of total renal blood flow (implantable flow probes), cortical blood flow (H2 Washout), GFR (creatinine clearance), and electrolyte excretion (flame photometry). Concomitant immunologic monitoring of T- lymphocyte function in the renal allograft, spleen, and blood will be performed by one way mixed lymphocyte reactions, cell mediated cytotoxicity assays, and interleukin-2 production and utilization by helper and cytotoxic T-lymphocytes. The strategy will be to inhibit "pro-rejection" eicosanoids (TXA2 and lipoxygenase products) and enhance production of anti-rejection eicosanoids (PGI2 and PGE2) by administering compounds that alter AA metabolism either alone or in combination. It is hypothesized that rational alterations in AA metabolism will result in improved graft function and survival. Correlation of alterations in T-cell function with changes in both renal allograft function and renal eicosanoid production during manipulation of AA metabolism should contribute to an understanding of the mechanisms involved in renal allograft rejection. In addition, renal damage occurring from ischemia-reperfusion and CYS nephrotoxicity may be associated with altered AA metabolism and maybe attenuated with agents directed at various arms of the AA cascade. |
0.905 |
1986 — 1989 | Anderson, Charles Berkheimer, Glenn Eick, Harry (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Educational Systems to Increase Student Achievement @ Michigan State University The purpose of this project is to design an approach to science instruction that takes into account some findings from cognitive research. It has been widely demonstrated that students come into the classroom with invalid perceptions about physical phenomena which are not altered by current forms of instruction. Through interviews, this project will document the general misconceptions held by students, identify these for teachers, and develop methods which directly confront the misconceptions. The student materials will consist of a unit, "Models of Matter", which will be modified to also confront the commonly held misconceptions. The final product will be an educational system that integrates learning activities and teaching strategies to cause conceptual change. The modified "Models of Matter" unit will be randomly assigned to 12 of 24 Lansing, Michigan Public School grade six classes to test its effectiveness in increasing student achievement and promoting recommended teaching strategies. The remaining 12 sixth grade classes will use the unmodified "Models of Matter" unit. The project expects to demonstrate how authors can use existing research findings to modify commercial textbook units and teacher guides to increase student learning. Since most teachers structure their teaching around a commercial textbook, the project has national significance for improving student achievement in science. |
0.967 |
1988 — 1991 | Riordan, Allen Lin, Yuh-Lang (co-PI) [⬀] Anderson, Charles |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ North Carolina State University The rapid development and intensification of winter cyclones in coastal regions presents a major weather forecasting problem. Along the East Coast of the United States, the development of cyclonic storms and frontal systems often occurs along the coastal region of the Carolinas. These weather systems may lead to severe weather in the heavily populated Northeast Corridor in the form of freezing rain, heavy snowfall, blizzards and extensive coastal erosion. A complex interaction of cold continental air, warm ocean currents, traveling atmospheric disturbances and local geography all appear to contribute to the rapid development of these systems; however, the processes are not well understood and the phenomena are often poorly forecast. In January-March 1986 a cooperative research project to study winter storms in this region was held by a consortium of universities and Federal agencies. Entitled GALE (Genesis of Atlantic Lows Experiment), the project was designed to provide detailed information on the role of air-sea interaction, planetary boundary-layer processes and mesoscale meteorological processes. As one of the investigators of the GALE, the Principal Investigator was instrumental in designing and executing the experiment. This research will extend initial analyses of data obtained during the GALE. Preliminary work reveals that the mesoscale structure is prevalent within the synoptic field and can better explain the observed precipitation and local weather than can the synoptic field. There is evidence, however, that mesoscale features occur in predictable patterns governed by the topography and synoptic-scale flow. The objectives of the research are to continue to identify and analyze mesoscale features in the atmospheric boundary layer over the near-shore waters and adjacent coastal plain and to explore the time- evolution of these features and their interactions with synoptic-scale systems especially as such interactions affect the precipitation process. |
0.969 |
1988 — 1992 | Anderson, Charles B [⬀] | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Renal Transplant Enhancement by Donor Specific Blood @ Washington University This proposal extends the research with donor specific transfusions and concomitant azathioprine immunosuppression (DST+A) in haplotype mismatched living donor kidney transplants to the cadaver situation. It is intended to demonstrate that pretreatment of potential renal allograft recipients with tissue typed and HLA-public antigen mismatched buffy coat transfusions (BCT) and concomitant azathioprine immunosuppression will result in improved cadaver renal allograft survival. Possible mechanisms of immunomodulation that suppress the allograft rejection response will be investigated in the blood (standard serologic and cellular immunologic tests) and in the allograft (fine needle aspiration) of the cadaver transplant recipient. The poteintial cadaver kidney transplant recipient will undergo three to six buffy coat transfusions over a six to ten week period from a single tissue typed volunteer donor (plasmapheresis program). Blood donors will be selected on the basis of the maximum number of public antigens mismatched for the recipient. A properly selected single donor can cover most of the public antigens not present in the recipient because of the limited number of different public anigens and their high frequency in the population. All recipients will receive continuous azathioprine immunosuppression starting prior to the transfusions and continuing into the posttransplant period. Cadaver kidney transplant will be performed two weeks to four weeks after the last transfusion using a donor kidney with public antigens the same as those present in the buffy coat transfusion. Recipients will undergo immunologic monitoring by: T- and B-cell crossmatch, mixed leukocyte reaction (MLR), antiidiotypic antibody analysis, interleukin 2 production during MLR, effects of recipient serum on the response to interleukin 2 (qualitative analysis), quantitative assay for interleukin 2 response inhibitory activity, and fine needle aspiration biopsy of the allograft analyzed for histocytology and cellular immunity. A major objective is to evaluate the contribution of IL-2 response inhibition to successful transplantation and its potential use as a test in assessing the induction of the salutary effects of DST+A/BCT+A. The ability to immunomodulate potential cadaver renal allograft recepients by down regulating the immune response to specific alloantigen would constitute an important advance in improving renal allograft survival over general nonspecific immunosuppressive measures. |
0.905 |
1989 — 1993 | Anderson, Charles Palincsar, Annemarie |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Michigan State University The project is a three year investigation of collaborative problem solving in science for the purpose of developing accounts of learning and problem solving by middle school students and developing instructional strategies and materials that improve both students' conceptual understanding of science and their capacities for self- regulation in complex problem solving situations. Year 1 is an intervention study investigating the comparative effects of three instructional conditions: a) mediated independent problem solving, b) group problem solving, and c) mediated group problem solving. This investigation will be conducted in eight classrooms as the students study a unit on the nature and properties of matter. Analyses of Year 1 data will occur in Year 2 for the purpose of: a) evaluating the success with which the desired outcomes were achieved across the various conditions in terms of conceptual understanding, self-regulatory abilities, and internalization of the social norms practiced across the three conditions, b) evaluating the reasons for the outcomes, principally through microanalysis of classroom interactions, and c) revising the instructional procedures. In Year 3, we will investigate the implementation of the revised instructional program in eight classrooms. The proposed study will contribute both to research on problem solving and conceptual understanding in science and to the improvement of educational practice, focusing on the opportunities for teachers and students to work together in "learning communities." |
0.967 |
1992 — 1994 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
The Generality and Practicality of Reinforcement Learning For Automatic Control @ Colorado State University Recent discoveries of the theoretical relationships between reinforcement learning and dynamic programming suggest exciting possibilities for developing automatic controllers that learn with experience to follow optimal control strategies. Combining reinforcement learning algorithms with the adaptive structure that neural networks provide results in theoretically optimal controllers that have more flexibility, and thus are more general, than current adaptive control techniques. However, for reinforcement learning networks to be practical, the efficiency with which they learn must be improved. In previous work, the PI identified one cause of slow learning to be difficulty of discovering useful features by the hidden units of the network. This difficulty has also been recognized within the supervisedlearning paradigm and a number of alternatives to the common error back propagation algorithm have been shown to significantly reduce learning time. These ideas will be extended to the reinforcement learning paradigm and their potential for reducing the learning time of reinforcement based networks will be explored. The objective is to alleviate the problem of training hidden units and to identify any remaining limitations of reinforcement learning networks that restrict their generality and practicality as real time control techniques. The methods will include both simulation studies and implementations as controllers of physical systems. |
1 |
1992 — 1996 | Aunon, Jorge Anderson, Charles |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Alternate Modes of Human-Computer Interaction: Eeg Recognition With Neural Networks @ Colorado State University This is the first year of a three year continuing effort. This research is to study the feasibility of human-computer interaction through the use of on-line recognition of electroencephalogram (EEG) patterns. A system that can identify, on-line, which of several mental tasks a person is performing could provide an alphabet with which a severely disabled person can compose commands to devices like a wheel chair. Most prior research has focused on recognition accuracy rather than on fast, real-time responses. The goals of this research are to characterize the limitations of current EEG recognition methods, to increase the accuracy and decrease the computation time of EEG recognition by use of a neural network approach, and to develop a practical real-time method. The performance of conventional methods and of neural network learning methods designed for high- dimensional data will be compared. Evaluations of feature and classifier characteristics will be based on classification accuracy, robustness and computation speed. This project has relevance to the field of pattern recognition in general, and to the neural network and human-computer interaction fields in particular. |
1 |
1993 — 1995 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Teaching For Conceptual Understanding and Self-Regulation Through Collaborative Problem Solving @ Michigan State University 9353099 Anderson The project is a three year investigation of collaborative problem solving in science for the purpose of developing accounts of learning and problem solving by middle school students and developing instructional strategies and materials that improve both students' conceptual understanding of science and their capacities for self-regulation in complex problem solving situations. Year 1 is an intervention study investigating the comparative effects of three instructional conditions: a) mediated independent problem solving, b) group problem solving, and c) mediated group problem solving. This investigation will be conducted in eight classrooms as the students study a unit on the nature and properties of matter. Analyses of Year 1 data will occur in Year 2 for the purpose of: a) evaluating the success with which the desired outcomes were achieved across the various conditions in terms of conceptual understanding, self-regulatory abilities, and internalization of the social norms practiced across the three conditions, b) evaluating the reasons for the outcomes, principally through microanalysis of classroom interactions, and c) revising the instructional procedures. In Year 3, we will investigate the implementation of the revised instructional program in eight classrooms. The proposed study will contribute both to research on problem solving and conceptual understanding in science and to the improvement of educational practice, focusing on the opportunities for teachers and students to work together in "learning communities." *** |
0.967 |
1995 — 1996 | Bohm, Anton Anderson, Charles Howe, Adele (co-PI) [⬀] Goss, Michael Beveridge, J. Ross |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Colorado State University 9422007 Beveridge This award is to purchase two shared-memory multiprocessor systems, one with accelerated 3D graphics as required by the following research projects: 1) Computer Vision and Graphics; 2) Combinatorial Optimization Using Local and Global Search; 3) Machine Learning for Classification and Control; 4) Planning Agents in Dynamic Simulated Environments; 5) Comparing Functional Programming Languages. Essential to these projeats is the computational power of the multiprocessors. The equipment will provide a means to gain experience mapping algorithms onto coarse grain parallel hardware. Many parallel algorithms in these projects require a shared memory multiprocessor architecture. The vision, graphics, learning and planning projects explicitly benefit from the 3D graphics capability of the hardware. In addition to the above projects, this equipment will be available for exploration of new areas of research. *** |
1 |
1995 — 1997 | Hittle, Douglas Anderson, Charles |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Control of Heating and Air-Conditioning Systems @ Colorado State University 9401249 Hittle The objective of this research project is to increase the efficiency of control methods for energy systems in buildings. IN meeting this objective, novel combinations of feedback controllers and neural network learning algorithms will be developed. to achieve the objective, recent developments in reinforcement learning methods for neural networks will be adapted to the HVAC system control problem. Neural networks will not be the sole source of control decisions for such a complex system. Adaptive schemes are notorious for leading to instabilities. to lessen the possibility of introducing instability, adaptive schemes will be integrated with existing, fixed controllers. the adaptive methods will only augment the control actions taken by the fixed controllers and a limit will be enforced on the degree to which the fixed controller's decision can be modified. This will result in a control system with an initial performance at the level provided by the original control designer. Then, with experience, the learning mechanism will be able to increase the performance of the controller beyond its initial ability. Results will certainly be of interest to building engineers, but will also advance the sate-of-the-art in neural networks for control. *** |
1 |
1998 — 2002 | Hittle, Douglas Anderson, Charles Young, Peter |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Robust Learning Control For Heating, Ventilating and Air- Conditioning Systems @ Colorado State University The primary objectives of the proposed research are: 1) Develop a new controller design methodology based around a combination of robust control and neural network reinforcement learning techniques. The strategy will combine the best aspects of robust control and reinforcement learning and yield a combined control design that is far more powerful than either acting alone. 2) Provide a theoretical framework for precisely analyzing the stability and performance properties of reinforcement learning controllers by exploiting and extending results from robust control theory. 3) Apply these results to the design of closed loop controllers by exploiting and extending results from robust control theory. 4) Implement and test these ideas on an experimental HVAC system. 5) Educate practitioners in industry about this new technology. 6) Integrate these ideas into systems and control curriculum. To accomplish these objectives, an interdisciplinary team has been formed consisting of a specialist in robust control from the Electrical Engineering Department, a specialist in reinforcement learning for neural networks from the Department of Computer Science, and a specialist in design, modeling and control of HVAC systems from the Mechanical Engineering Department. This interdisciplinary approach will advance the state-of-the-art in the theory of robust reinforcement learning control design, demonstrate these new methods on an experimental HVAC system and provide much needed improved methods for controlling HVAC systems in buildings. Eventual wide spread implementation of these schemes in buildings around the world will reduce energy consumption and extend equipment life. |
1 |
2002 — 2012 | Anderson, Charles Kirby, Michael (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Geometric Pattern Analysis and Mental Task Design For a Brain-Computer Interface @ Colorado State University The goal of this project is to develop novel electroencephalogram (EEG) classification methods that result in a practical, real-time brain-computer interfaces (BCI) system. BCIs are hardware and software systems that sample EEG signals from electrodes placed on the scalp and extract patterns from EEG that indicate the mental activity being performed by the person. The long-term goal of this line of research is a new mode of communication for victims of diseases and injuries resulting in the loss of voluntary muscle control, such as amyotrophic lateral sclerosis (ALS), high-level spinal cord injuries or severe cerebral palsy. The autonomic and intellectual functions of such subjects continue to be active. This can result in a "locked-in" syndrome in which a person is unable to communicate to the outside world. The interpretation of information contained in EEG may lead to a new mode of communication with which subjects can communicate with their care givers or directly control devices such as televisions, wheel chairs, speech synthesizers and computers. |
1 |
2003 — 2007 | Hittle, Douglas Anderson, Charles Young, Peter |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Robust Learning Control For Building Energy Systems @ Colorado State University This project will develop of new control strategies for heating, ventilating, and air-conditioning (HVAC) systems that combine artificial intelligence and robust control theory. A primary objective of the work is to develop learning controllers, which provide (a-priori) guaranteed closed-loop stability even while the controller trains online. It is a follow-on project to NSF project 9804757, i8Robust Learning Control for Heating, Ventilating and Air-Conditioning Systems, it where several significant advancements in the state of the art were achieved. |
1 |
2004 — 2008 | Anderson, Charles Kirby, Michael [⬀] Beveridge, J. Ross Peterson, Christopher (co-PI) [⬀] Kley, Holger (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Mspa-McS: New Tools For Algebro-Geometric Data Analysis @ Colorado State University ABSTRACT |
1 |
2005 — 2009 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Michigan State University This project will study the development of a learning progression: a coherent account of the development of students' reasoning about the role of carbon in environmental systems, based on old and new research. The role of carbon in environmental systems includes physical and chemical changes in matter, growth and decay of plants and animals, photosynthesis and cellular respiration, matter cycling and energy flow in ecosystems, and the effects of humans and human technologies on these processes. Products of this project will include: |
0.967 |
2006 — 2010 | Anderson, Charles Conner, Jeffrey (co-PI) [⬀] Mittelbach, Gary (co-PI) [⬀] Getty, Thomas (co-PI) [⬀] Robertson, G. Philip [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Track 1, Gk-12: Ecological Literacy in the K-12 Classrooms of Rural Michigan @ Michigan State University This proposal describes a Track 1 project designed to bring inquiry-based learning to schools in rural Michigan. Eight graduate Fellows will connect with teachers to learn pedagogical skills and bring ecological concepts to schools. Eleven Faculty at Kellogg Biological Station will be involved in several aspects of the project. |
0.967 |
2008 — 2012 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Learning Progression On Carbon-Transforming Processes in Socio-Ecological Systems @ Michigan State University DRL-0815993 |
0.967 |
2008 — 2015 | Tschillard, Raymond Moore, John Whitmer, Allison Anderson, Charles Berkowitz, Alan |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Targeted Partnership: Culturally Relevant Ecology, Learning Progressions and Environmental Literacy @ Colorado State University Driven by an environmental science literacy framework around learning progressions within core science and mathematics concepts complemented with citizenship, this targeted partnership connects the research and education prowess in the environmental sciences of universities and sites within the NSF-funded Long Term Ecological Research (LTER) Network with teacher professional development in science and mathematics of partner middle schools and high schools. The project extends across the nation, involving four LTER research sites and 22 K-12 schools/districts with direct impacts on over 250 science and mathematics teachers and 70,000 students of highly diverse backgrounds. The work focuses on coupled human-ecosystem interactions in the context of socio-ecological systems as a framework to develop a culturally relevant ecology from both a scientific and educational perspective. The following research, professional development and institutional goals unify the project: |
1 |
2009 — 2012 | Anderson, Charles Merrill, John |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Michigan State University This project builds on a one year Phase 1 project in which ecology faculty began to use Diagnostic Question Clusters (DQCs) to: 1. organize an entire introductory course around key concepts and biologically principled thinking based on an overarching framework and 2. identify and gauge student progress on specific principles especially problematic for them. The DQCs focus on energy and matter across all levels of biological organization. Faculty from universities, including Historically Black Colleges, plus four year and community colleges contributed to the original DQC research. Adopting an expanding networks approach for broader dissemination and impact, this project extends this model to more faculty and also introduces modifications to the faculty workshops based on the "lessons learned" from the previous project. |
0.967 |
2010 — 2014 | Anderson, Charles Rice, Mary Jane |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Michigan State University Interdisciplinary (99) |
0.967 |
2010 — 2014 | Gunckel, Kristin Anderson, Charles Covitt, Beth |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Reasoning Tools For Understanding Water Systems @ University of Montana This exploratory project, led by faculty at the University of Montana, Michigan State University, and the University of Arizona, collaborating with teachers from the Missoula, MT schools, builds on current learning progression research to study the effects of teaching Tools for Reasoning on development of middle school students' capacities to understand the Earth's hydrologic systems. The project applies a design-based research approach using iterative cycles of Tool design/revision, teacher workshops, and small-scale pilot tests of Tools through classroom experiments with teachers and students in Montana and Arizona. |
0.948 |
2010 — 2016 | Lau, Jennifer (co-PI) [⬀] Lau, Jennifer (co-PI) [⬀] Gross, Katherine (co-PI) [⬀] Anderson, Charles Getty, Thomas [⬀] Robertson, G. Philip (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Michigan State University Abstract: Using the STEM Dimensions of Bioenergy Sustainability |
0.967 |
2010 — 2016 | Wilson, Mark Schwille, Kathleen Mohan, Lindsey (co-PI) [⬀] Anderson, Charles Gallagher, Daniel |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Michigan State University This project--led by science educators at Michigan State University, the National Geographic Society, the Natural Resource Ecology Laboratory (NREL) at Colorado State University, the Berkeley Evaluation and Assessment Research (BEAR) Center, and AAAS Project 2061, and including schools in California, Colorado, Maryland, Michigan, and Washington--builds on prior efforts with learning progressions, and is focused on key carbon-transforming processes in socio-ecological systems at multiple scales, including cellular and organismal metabolism, ecosystem energetics and carbon cycling, carbon sequestration, and combustion of fossil fuels. |
0.967 |
2011 | Anderson, Charles [⬀] | F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Cortical Microcircuit Dysfunction as a Result of Met Deficiency: a Link to Autism @ Northwestern University At Chicago DESCRIPTION (provided by applicant): Autism spectrum disorder (ASD) affects as many as 1 in 150 children. It is a complex developmental disorder characterized by social deficits, language impairment, and restricted interests (Newschaffer et al., 2007;Levitt and Campbell, 2009). Genetic linkage techniques recently revealed that individuals with ASD are three times more likely to have a mutation in the promoter region of the gene for MET receptor tyrosine kinase (hereafter MET), which results in reduced MET expression (Campbel et al., 2006;Campbel et al., 2007). The MET signaling pathway is important for the normal development of the cerebral cortex (Powell et al., 2001;Powell et al., 2003;Levitt et al., 2004;Gutierrez et al., 2004). Interference with this pathway affects cortical development in a number of ways. Still unknown however, is the extent to which the functional organization of cortical circuits is affected by MET dysfunction. Of particular interest to ASD research is the synaptic organization of the frontal cortex, which is involved in many higher order cognitive aspects of behavior and executive functioning. Evidence suggests long-range under-connectivity between cortical areas in ASD (Horwitz et al., 198;Courchesne and Pierce, 2005;Kana et al., 2007). From this view, ASD is a disorder of cortical circuits. It has been proposed that there is also an over-strengthening of local connectivity in ASD (Courchesne and Pierce, 2005), but this has yet to be directly measured. The availability of a MET- knockout (MET-KO) mouse will allow me to measure changes in synaptic connectivity that result from interference with the MET signaling pathway. I hypothesize that local synaptic connections in frontal cortex are over-strengthened as a result of MET- KO. I will test this hypothesis by measuring the circuit abnormalities of corticostriatal neurons with high throughput circuit mapping techniques (Weiler et al., 2008;Yu et al., 2008;Wood et al., 2009, Anderson 2010). I will focus on corticostriatal neurons because these neurons provide long-range input to other cortical areas (Wilson, 1987;Reiner et al., 2003) and the projection is a key component in loops linking the frontal cortex with the basal ganglia and the thalamus important for the selection and initiation of behavior (Albin et al., 1989). Understanding altered cortical connectivity in MET-KO will be an important step towards characterizing the nature of cortical circuit disorders associated with ASD. It will provide a basis for understanding the mechanisms underlying the changes to the brain in ASD. PUBLIC HEALTH RELEVANCE: As many 1 in 150 children are diagnosed with autism spectrum disorder (ASD), which is a complex developmental disorder characterized by abnormal social interactions, language deficits, and restricted interests. Evidence implicates alterations to the circuits of the frontal cortex in ASD, but to date, no detailed, cell-level resolution of synaptic connectivity in non-syndromic ASD has been obtained. We will characterize the cortical circuits of a mouse model of cortical circuit dysfunction in ASD, which will yield important insight into the mechanism underlying differences in the synaptic organization of the frontal cortex, and help understand the changes that occur in the brains of people with ASD. |
0.942 |
2011 — 2012 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Learning Progressions Footprint Conference @ Michigan State University Through the "Learning Progressions Footprint Conference," leading researchers in science and mathematics education are bringing together leaders in the field for a workshop - to take place in Washington, DC, in July, 2011 - that will enable them to take stock of the progress of learning progressions research to date and to suggest productive directions for future research and development. The year 2011 promises to be a watershed year in science and mathematics education as many important developments are currently taking place that will shape mathematics and science education for years to come. In particular, new national standards are under development in both mathematics and science education, with revisions in state standards and assessments to follow. Learning progressions are informing Common Core standards and assessments for mathematics and are expected to play a central role in the conceptual framework for new National Science Education Standards. As new standards and assessments are introduced to the field, it will be critical (a) to assess current standards and contributions of learning progressions research, and (b) to turn attention to research on how to support implementation of practices and related products and technologies informed by a learning progressions perspective. |
0.967 |
2011 — 2017 | Anderson, Charles Davies, Patricia (co-PI) [⬀] Gavin, William |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Hcc: Medium: Removing Barriers to the Practical Use of Non-Invasive Brain-Computer Interfaces @ Colorado State University Brain-computer interfaces (BCIs) are hardware and software systems that allow users to interact with computer applications by changing their mental activity, which causes variations in weak electrical voltages produced by the brain. BCIs measure these voltages in one of two ways: invasive methods use electrodes implanted in the brain, while noninvasive methods use electrodes resting on the scalp that are part of a cap worn by the user. A long-term goal of BCI research is a new mode of communication for subjects with diseases and injuries resulting in the loss of voluntary muscle control, such as amyotrophic lateral sclerosis (ALS), multiple sclerosis, high-level spinal cord injuries or severe cerebral palsy. If all voluntary muscle control is lost, a locked-in syndrome results in which a person is unable to communicate with the outside world. BCIs can provide a new way for users to communicate with their caregivers and to control devices such as televisions, wheelchairs, speech synthesizers and computers. While BCI technology holds great promise, most BCI systems remain in research labs. The goal of this project is to remove barriers to practical, noninvasive, BCI technology that exist in current approaches, and to field test the resulting BCI systems in the homes of users who suffer from motor impairments. Limitations of current BCI systems that will be addressed include the difficulty of applying an electrode cap, signal artifacts due to other assistive technology in the user's environment, and long computer and user training times required to calibrate current EEG classification algorithms. |
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2013 — 2016 | Paustian, Keith [⬀] Anderson, Charles Guggemos, Angela Bradley, Thomas Dunbar, Brian |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Colorado State University This Partnerships for Innovation: Building Innovation Capacity (PFI:BIC) project from Colorado State University will develop a state-of-the-art system integrating greenhouse gas (GHG) emissions modeling, energy modeling, and life cycle assessment (LCA) for the built environment. This new Carbon Footprint Metric (CFM) system will mesh seamlessly with existing design and construction management tools that are widely used by architects, engineers and builders. The system will provide dynamic, real-time, 'on the-fly' carbon footprint measurements, all the way from the building concept stage through to construction and building completion and operation. |
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2014 | Anderson, Charles [⬀] | F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Synaptic Zinc Release in the Dorsal Cochlear Nucleus: Implications For Tinnitus @ University of Pittsburgh At Pittsburgh DESCRIPTION (provided by applicant): Tinnitus - the perception of phantom sounds -is frequently caused by acoustic trauma. This widespread neurological condition affects approximately 40 million people in the U.S. Recent evidence suggests that the auditory brainstem, and in particular, the dorsal cochlear nucleus (DCN), plays a crucial role in the induction of tinnitus. The DCN displays hyperexcitability in tinnitus, hypothesized to result from endogenous compensatory mechanisms in response to acoustic trauma, termed maladaptive plasticity. Multiple mechanisms have been proposed to account for changes to the DCN in tinnitus, but to date, there has been no consensus as to how this brainstem nucleus transitions into a pathological state during this disorder. The DCN has a well-defined synaptic organization and contains multiple inhibitory and excitatory pathways that shape the response properties of this structure to sound. There are a rich variety of synaptic plasticity mechanisms present in the DCN, so factors that influence synaptic plasticity are potential substrates for the chronic hyperexcitability observed in the DCN during tinnitus. The DCN is unique among the auditory brainstem nuclei because it contains high levels of synaptic zinc - a strong regulator of long-term plasticity. Zinc is released from glutamatergic terminals during synaptic transmission, and because it potently inhibits NMDA receptors, it is poised to have a dramatic effect on synaptic signaling. My preliminary data indicate that mice with behavioral evidence of tinnitus have a dramatic reduction of synaptic zinc released from the DCN. This is a novel neurophysiological correlate of tinnitus. I hypothesize that synaptic zinc is critical for the normal functioning of the DCN and tht the loss of zinc is crucial feature of the pathology of the DCN during tinnitus. My preliminary data suggest that reduced synaptic zinc release leads to reduced inhibitory drive in the DCN. This has the potential to change to the balance of excitation and inhibition in the DCN, and be a contributing factor to the hyperexcitability of this structure in tinnitus. I will use newly developed ratiometric fluorescent zinc sensors and chelators in combination with brain slice electrophysiology to examine the role of synaptic zinc in the DCN in normal hearing and in tinnitus. My results will shed new light onto the mechanisms by which the DCN transitions into a state of pathological hyperactivity and potentially offer new strategies for therapeutic interventions for tinnitus. |
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2014 — 2019 | Anderson, Charles Getty, Thomas (co-PI) [⬀] Schwille, Kathleen Covitt, Beth Gallagher, Daniel Spiegel, Samuel |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Sustaining Responsive and Rigorous Teaching Based On Carbon: Transformations in Matter and Energy @ Michigan State University Successful science teachers need high quality teaching materials, sustained professional development opportunities, and a school structure that aligns local goals and policies, and supports sustained teacher networks. This project addresses all three of these essential elements in the context of a key topic in the sciences: the role of carbon in the flow of materials and energy through living systems, human engineered systems, and Earth systems at multiple scales. The project builds on previously funded projects that have developed student learning progressions for these topics, and it will develop and test a new professional development model for teachers that is based on a teacher learning progression framework. The framework is based on four core teaching and learning practices advocated by the Next Generation Science Standards (NGSS): formative assessment, inquiry, explanations, and decision making. Online and in-person teacher networks will also be developed and studied for their effects on teacher knowledge and practices, and on student learning. |
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2016 — 2017 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Sixth International Brain-Computer Interface Meeting @ Colorado State University Brain-computer interface (BCI) technology is a potentially powerful communication and control option for people with severe motor disabilities, as well as a hands-free, voice-free control option for mainstream users. The success of this exciting work depends on close and productive multidisciplinary interactions among researchers working in neuroscience, psychology, engineering, mathematics, computer science, and clinical rehabilitation. For this reason, the Sixth International Brain-Computer Interface meeting , themed "BCI Past, Present, and Future", will be held May 30 - June 3, 2016, at the Asilomar Conference Grounds, Pacific Grove, California. The 2016 BCI Meeting will retain the unique, highly interactive, student-friendly, retreat-like atmosphere and high-impact activities that are the hallmarks of the BCI Meeting series, starting with the first BCI meeting in 1999. |
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2016 — 2019 | Anderson, Charles Ben-Hur, Asa [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Colorado State University Proteins perform many cellular functions, made possible by complex networks of interactions; knowing the location of the interaction sites on the proteins is key for understanding exactly how they work. Important applications include designing drugs and therapeutic agents. Experimental techniques for determining the interfaces between proteins are expensive and time consuming, so computational structural biologists seek to predict these mathematically. Current prediction methods use a limited number of features hand-crafted by an expert. An alternate approach is to learn the important features directly from all of the data, using a method called deep neural networks. This proposal explores a combined approach: use expert intuition for some features but add the power of unsupervised learning with deep neural networks to learn additional, novel features. The results will enrich the way protein structural features are understood in terms of their functional properties, whether those are catalytic sites, protein-binding sites or other sites important to the protein structure. Certainly in the prediction of protein structure itself machine learning scoring methods are showing great promise. Aspects of the research will be used in courses offered through a recently awarded NSF-NRT training grant, The training grant establishes an interdisciplinary program at the interfaces of biology, engineering, math/statistics and computer science. The program prepares students for a variety of career paths. Research and education experiences will provide students with valuable expertise in a computational area that is highly valued by top technology firms, such as Google and Facebook, which have research teams exploring the possibilities of deep neural networks. |
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2016 — 2019 | Thomas, Claire Keating, Christine (co-PI) [⬀] Wang, James Anderson, Charles [⬀] Rosa, Cristina |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Pennsylvania State Univ University Park An award is made to The Pennsylvania State University, University Park campus to purchase a super-resolution microscope that will enable the capture of images of plant and animal cells, as well as complex chemical samples, at the scale of single molecules. This microscope will reveal new insights into how living and chemical systems are organized and work. The project will also generate new image analysis tools for the scientific community. The microscope will enable interdisciplinary research training and enhance education through coursework and outreach to other Penn State campuses and other institutions. Integration of this microscope into a core microscopy facility will make it available to undergraduate, graduate and postdoctoral trainees, and regular imaging workshops will be offered by Penn State. New teaching modules for K-12 and undergraduate educators demonstrating the science of size and the potential of super-resolution microscopy will be developed. Access and training will be assured for underrepresented students through programs including the Summer Experience in the Eberly College of Science, McNair Scholars, Women in Science and Engineering Research, and Minority Undergraduate Research Experience. Public understanding of super-resolution microscopy and its advantages will be catalyzed by multiple outreach activities and venues, including The Franklin Institute (science museum) and Penn State's Ag Progress Days, which together will expose this cutting-edge imaging technology to tens of thousands of people. The discoveries enabled by this microscope will advance the study of plant and animal development, sustainable agriculture and energy production, and the chemical interactions that define our physical environment. |
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2016 — 2020 | Puri, Virendra (co-PI) [⬀] Wang, James Anderson, Charles [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Integrated Molecular, Dynamic Imaging, and Modeling Analysis of Stomatal Guard Cell Walls @ Pennsylvania State Univ University Park This project seeks to determine how the carbohydrate-based cell walls of guard cells dynamically change shape to control stomatal pore size, thus allowing plants to control carbon dioxide (CO2) uptake and water loss. Stomata are small openings in the surfaces of plants that regulate the photosynthetic conversion of CO2 into plant biomass, which serves as a renewable source of food, materials, and bioenergy. A deeper understanding of cell wall structure, mechanics, and dynamics in stomatal guard cells will help identify plants that can more efficiently use water, a major limiting factor in global agricultural production. The computational image analysis and modeling tools that will be developed in this project will provide scientists with new ways of interpreting and understanding experimental data. Because stomatal guard cells are an amazing example of cellular engineering by plants and are accessible and observable by scientists of all ages, a learning module will be developed and deployed that allows 4th through 8th graders to observe stomatal dynamics first-hand and challenges them to construct and optimize functioning macro-scale models of stomatal guard cells, helping to inspire future scientists and engineers. This project will also train two PhD students and a research associate in interdisciplinary research skills that cross the boundaries of biology, computer and information science, and engineering. |
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2018 — 2019 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Student Support For the Seventh International Brain-Computer Interface Meeting @ Colorado State University Brain-computer interface (BCI) research explores avenues of controlling devices directly from brain signals. Thus, BCI technology is a powerful control option for neuro-prosthetic limbs, as well as a potential communication option for people with severe motor disabilities or disorders such as amyotrophic lateral sclerosis (ALS), brainstem stroke, cerebral palsy, and spinal cord injury, who may have little or even no muscle control and therefore no means of communication with the external world. The International Brain-Computer Interface (IBCI) meeting is the flagship conference for the field, the seventh of which will be held May 21-25, 2018, on the Asilomar Conference Grounds in Pacific Grove,, California. Effective BCI research requires interdisciplinary interactions involving neuroscience, psychology, engineering, mathematics, computer science, and clinical rehabilitation, and the IBCI meeting serves as a critical catalyst for technology dissemination, new collaborations, and educational opportunities for students. The primary source of funding for the meeting is the National Institutes of Health (NIH). This NSF funding will enable another 22 students, including undergraduate and graduate students and postdoctoral fellows, to attend and participate in the conference. The organizers are planning innovations to make the 2018 event the most valuable yet. For the first time the conference will include a series of 12 one-hour masterclasses, six of which will meet in parallel on Wednesday evening, and the other six will meet in parallel on Thursday afternoon. Each masterclass will have a senior researcher as the "master" along with two students each of whom will present his/her research for 10-15 minutes, after which the master will provide wise and constructive comments, with audience participation encouraged in an informal session intended to give students access to senior expertise and to get good tips for their research. Another new event at this year's meeting with be the "BCI Hackathon" organized and sponsored by G.Tec Medical Engineering GmbH, during which participants will work in teams on a number of BCI applications and will then present their work to the hackathon community. NSF funding will be used to support student travel, registration, and student-only event costs. Student participation in previous IBCI meetings has been very fruitful; a large number of those students have now graduated and are prominent researchers in the BCI field. The organizers are actively recruiting student attendees from traditionally underrepresented groups. More information about the conference may be found online at http://bcisociety.org/meetings/bci-2018-welcome/. |
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2020 — 2021 | Anderson, Charles [⬀] | R35Activity Code Description: To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential. |
Synapse-Specific Effects of Synaptically Released Zinc: Implications For Auditory Processing @ West Virginia University Project Summary Many regions of the brain including the cortex, hippocampus, basal ganglia, and limbic structures are highly enriched with synaptic zinc. Synaptic zinc (as Zn2+) is loaded into presynaptic vesicles by zinc transporter 3 (ZnT3), where it is coreleased with glutamate during synaptic transmission. Since synaptic zinc inhibits AMPA and NMDA receptors ? which mediate the majority of excitatory glutamatergic transmission in the brain ? synaptic zinc can modulate excitatory synaptic signaling. ZnT3 KO mice (which lack synaptic zinc) display a range of cognitive and sensory impairments and demonstrate behavioral deficits associated with autism and schizophrenia. Mounting evidence from human populations shows that mutations in certain zinc transporters are linked with major neurological disorders such as schizophrenia. Together, these findings strongly suggest that synaptic zinc signaling is important for neuronal processing. The goals of this project are to understand how synaptic zinc contributes to normal neuronal function and how disruptions in zinc signaling are linked to pathological neuronal conditions. We will take three complimentary experimental approaches to these questions. 1) Using ex vivo brain slice preparations and optogenetic stimulation paradigms, we dissect the roles of synaptic zinc in shaping the dynamics of synaptic transmission at specific synaptic connections in cortical microcircuits. 2) Using in vivo 2-photon calcium imaging, we assess the roles of synaptic zinc in shaping the sensory-evoked responses of specific classes of auditory cortical neurons in awake mice. 3) Using in vitro high-throughput screening assays and rational compound design approaches, we are designing novel tools to modulate the function of specific zinc transport proteins. Together these approaches will allow us to answer fundamental questions concerning the role of synaptic zinc in brain function and provide new mechanistic insights into endogenous mechanisms that shape synaptic and neural processing. |
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2020 — 2021 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Student Support For the Eighth International Brain-Computer Interface Meeting @ Colorado State University Brain-computer interface (BCI) research explores avenues of controlling devices directly from brain signals. Thus, BCI technology is a powerful control option for neuro-prosthetic limbs, as well as a potential communication option for people with severe motor disabilities or disorders such as amyotrophic lateral sclerosis (ALS), brainstem stroke, cerebral palsy, and spinal cord injury, who may have little or even no muscle control and therefore no means of communication with the external world. The International Brain-Computer Interface (IBCI) meeting is the flagship conference for the field. Effective BCI research requires interdisciplinary interactions involving neuroscience, psychology, engineering, mathematics, computer science, and clinical rehabilitation, and the IBCI meetings serve as critical catalysts for technology dissemination, new collaborations, and educational opportunities for students. The IBCI conferences are under the auspices of the BCI Society, and in light of the significant progress that has been made towards restoring communication and mobility the 2020 International BCI meeting will focus on emerging applications and techniques with the theme "BCIs: The Next Frontier." NSF funding will enable an additional 25 students, including undergraduate and graduate students and postdoctoral fellows, to participate in the conference. Student participation in previous IBCI meetings has been very fruitful; many of those students have now graduated and are prominent researchers in the BCI field. The organizers are actively working to recruit student attendees from traditionally underrepresented groups. |
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2020 — 2021 | Anderson, Charles | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Eager: Detecting Real and Imagined Movement of Individual Fingers From Scalp Eeg @ Colorado State University The long-term goal of brain-computer interface (BCI) research is to establish a new mode of communication for individuals who have lost some or all voluntary muscle control due to injury or degenerative diseases such as amyotrophic lateral sclerosis, multiple sclerosis, and severe cerebral palsy. If all voluntary muscle control is lost, a locked-in syndrome results in which a person is unable to communicate with the outside world. BCIs could potentially provide a way for these individuals to communicate with their caregivers and to control devices such as televisions, wheelchairs, and robot assistants. While BCI technology holds great promise, non-invasive BCI systems are not yet practical, primarily due to limitations in signal quality provided by current electroencephalogram (EEG) scalp electrodes. This project will explore initial steps towards a research plan that will transform BCI technology in ways that will enable breakthroughs in the reliability and accuracy of BCI applications. After years of limited advances in BCI accuracy and reliability, project outcomes will accelerate the design of new BCI applications to significantly improve the quality of life for many persons who are in dire need of help. The project will also play a strong role in the interdisciplinary education of computer science and biomedical students. |
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2020 — 2023 | Wang, James Anderson, Charles [⬀] Yi, Hojae |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ Pennsylvania State Univ University Park In plants, stomatal guard cells influence both photosynthesis and water transport and are thus essential for growth and efficient water use. However, our understanding of guard cell function at the cellular and molecular levels is limited. This project studies how guard cells dynamically expand and shrink to open and close stomatal pores, controlling the uptake of carbon dioxide and the release of oxygen and water by the plant. Understanding how guard cells function will aid in the development of resilient, high-yielding crops that can grow in hot, dry environments and more effectively remove carbon dioxide from the atmosphere. The image analysis and modeling tools created in this project will allow researchers to predict the behavior of a wide range of mechanical behaviors and responses by cells. This multidisciplinary project will train three PhD students as future leaders across the topics of cell biology, computational image analysis, and mechanical testing and modeling of biological systems, and will spread knowledge of guard cells and plant biology using learning modules and research experiences for K-12 and undergraduate students. |
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