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High-probability grants
According to our matching algorithm, John R. Doucet is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2000 — 2002 |
Doucet, John R |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Functional Pathways of the Cochlear Nucleus @ Johns Hopkins University
Our long term goal is to understand the neural codes and computations that underlie hearing. All acoustic information is presented to the brain with the synapses formed by auditory nerve fibers in the cochlear nucleus. Here, the data contained in the nerve are distributed amongst a variety of cell types that each represent some feature of the acoustic environment. Cochlear nucleus neurons and their neural codes form the foundation of central auditory pathways that are ultimately responsible for our ability to locate and identify a sound: perceptions that collectively we refer to as hearing. How and where the neural computations that underlie these perceptions occur will depend on the axonal pathways engendered by distinct classes of cochlear nucleus neurons, and their synaptic organizations in the structures that they target. In this proposal, we plan to study the axonal pathways borne by one large group of cochlear nucleus neurons referred to as multipolar neurons. We propose that multipolar neurons in the ventral division of the cochlear nucleus play a key role in the initial stages of acoustic information processing. They are full participants in the intrinsic circuitry of the cochlear nucleus and their axons target every brain stem nucleus in the auditory pathway. Multipolar neurons are a heterogeneous population, suggesting that they are comprised of several distinct subclasses of cells. We propose to use retrograde pathway tracing methods to identify the targets of different populations of multipolar neurons, and electrophysiological recording techniques to match the axonal pathway of each type with its physiological response properties. These data will provide new knowledge with respect to the functional roles served by a large group of cochlear nucleus cells, as well as provide insights into the nature of the neural computations performed in central auditory nuclei.
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1 |
2003 — 2006 |
Doucet, John R |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Studies of the Central Auditory System @ Johns Hopkins University
DESCRIPTION (provided by applicant): Our long-range goal is to understand the neural mechanisms of hearing. All information about sound is encoded by patterns of activity in the auditory nerve. By virtue of its position as the obligatory recipient of auditory nerve input, the cochlear nucleus is a key site to study how acoustic stimuli are translated into neural codes that are then sent to the brain. Cochlear nucleus neurons are organized into definable groups that share common inputs, cellular mechanisms, and axonal targets. By linking structure and function for different cell types, we seek to understand their roles in hearing. Ultimately, this kind of knowledge should allow us to interpret structural anomalies resulting from deafness or noise-induced damage in terms of their effect on acoustic processing. In this application, we propose to study multipolar cells in the ventral division of the cochlear nucleus. The axons of these cells target other neurons in the cochlear nucleus. They also project to nearly every brain stem and midbrain structure in the auditory pathway. Multipolar neurons are comprised of several distinct subclasses of cells. We will use pathway tracing and immunocytochemical techniques to study the structure and neurochemistry of different classes with respect to their axonal targets. We will employ an in vitro preparation of the isolated whole brain to study how the activity within a subclass influences its axonal targets. Information obtained from both types of experiments will result in links between structural and functional data for different cell types. This combined anatomic and physiologic approach to the study of multipolar cells will allow us to determine how their encoded messages are distributed in the brain, will impact models of binaural hearing, and may suggest new designs for human brain stem implants.
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1 |