Michael R. Botts, Ph.D.

Affiliations: 
University of Wisconsin, Madison, Madison, WI 
Area:
fungal development and virulence
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Christina M. Hull grad student 2012 UW Madison
 (Determination of the molecular properties of Cryptococcus neoformans spores that contribute to the development, differentiation, and virulence of these infectious particles.)
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Publications

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Walsh NM, Botts MR, McDermott AJ, et al. (2019) Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus. Plos Pathogens. 15: e1007777
Davis JM, Huang M, Botts MR, et al. (2016) A Zebrafish Model of Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells and Neutrophils in the Establishment and Control of Sustained Fungemia. Infection and Immunity
Botts MR, Cohen LB, Probert CS, et al. (2016) Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host. G3 (Bethesda, Md.)
Luallen RJ, Reinke AW, Tong L, et al. (2016) Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans. Plos Pathogens. 12: e1005724
Barkal LJ, Walsh NM, Botts MR, et al. (2016) Leveraging a high resolution microfluidic assay reveals insights into pathogenic fungal spore germination. Integrative Biology : Quantitative Biosciences From Nano to Macro
Szumowski SC, Estes KA, Popovich JJ, et al. (2015) Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells. Cellular Microbiology
Botts MR, Huang M, Borchardt RK, et al. (2014) Developmental cell fate and virulence are linked to trehalose homeostasis in Cryptococcus neoformans. Eukaryotic Cell. 13: 1158-68
Szumowski SC, Botts MR, Popovich JJ, et al. (2014) The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans. Proceedings of the National Academy of Sciences of the United States of America. 111: 8215-20
Botts MR, Hull CM. (2010) Dueling in the lung: how Cryptococcus spores race the host for survival. Current Opinion in Microbiology. 13: 437-42
Giles SS, Dagenais TR, Botts MR, et al. (2009) Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infection and Immunity. 77: 3491-500
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