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F. A. Romero, Ph.D.

Affiliations: 
University of Kansas, Lawrence, KS, United States 
Area:
neurotransmitters and drugs affecting them in the central nervous system
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"F. Romero"
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Parents

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Gary L. Grunewald grad student 2004 University of Kansas
 (Exploring the active site of phenylethanolamine N-methyltransferase: 1,2,3,4-Tetrahydroisoquinoline-type inhibitors.)

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Publications

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Romero FA, Du W, Hwang I, et al. (2007) Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 1058-68
Grunewald GL, Romero FA, Criscione KR. (2005) Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. Journal of Medicinal Chemistry. 48: 1806-12
Grunewald GL, Romero FA, Seim MR, et al. (2005) Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Bioorganic & Medicinal Chemistry Letters. 15: 1143-7
Grunewald GL, Romero FA, Chieu AD, et al. (2005) Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors. Bioorganic & Medicinal Chemistry. 13: 1261-73
Grunewald GL, Romero FA, Criscione KR. (2005) 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity. Journal of Medicinal Chemistry. 48: 134-40
Romero FA, Vodonick SM, Criscione KR, et al. (2004) Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor. Journal of Medicinal Chemistry. 47: 4483-93
Lankin DC, Grunewald GL, Romero FA, et al. (2002) The NH---FC dipole orientation effect for pendant exocyclic CH(2)F. Organic Letters. 4: 3557-60
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