A Claudio Cuello, OC, MD, DSc, FRSC, FMedSci, FMedSci

1985- Pharmacology And Therapeutics McGill University, Montreal, QC, Canada 
Alzheimer's Disease, cognitive behavior, neurochemistry, immunocytochemistry, neuropharmacology and molecular biology.
"A Claudio Cuello"

Since 2003, he has been the Charles E. Frosst/Merck endowed Chair in Pharmacology at McGill University. He leads a research team on multidisciplinary aspects (cognitive behavior, neurochemistry, immunocytochemistry, neuropharmacology and molecular biology) of brain aging and Alzheimer’s disease neuropathology. The Cuello Lab is comprised of talented and motivated colleagues focused on unravelling the earliest biochemical-pathological events of the Alzheimer’s pathology as well as searching for early biomarkers and novel experimental therapies to arrest or revert the early Alzheimer’s pathology. His group has recently made important contributions to the understanding of CNS trophic factor deregulation both in Alzheimer’s disease and in Down syndrome.

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Mean distance: 13.39 (cluster 11)
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Orciani C, Hall H, Pentz R, et al. (2022) Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. Journal of Neurochemistry
Flores-Aguilar L, Hall H, Orciani C, et al. (2022) Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of Alzheimer's disease. Neuropathology and Applied Neurobiology. e12835
Wong C, Barkai O, Wang F, et al. (2022) mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. The Journal of Clinical Investigation
Do Carmo S, Kannel B, Cuello AC. (2021) The Nerve Growth Factor Metabolic Pathway Dysregulation as Cause of Alzheimer's Cholinergic Atrophy. Cells. 11
Do Carmo S, Spillantini MG, Cuello AC. (2021) Editorial: Tau Pathology in Neurological Disorders. Frontiers in Neurology. 12: 754669
Do Carmo S, Kannel B, Cuello AC. (2021) Nerve Growth Factor Compromise in Down Syndrome. Frontiers in Aging Neuroscience. 13: 719507
Sosulina L, Mittag M, Geis HR, et al. (2021) Hippocampal hyperactivity in a rat model of Alzheimer's disease. Journal of Neurochemistry
Habif M, Do Carmo S, Báez MV, et al. (2020) Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis. Frontiers in Aging Neuroscience. 12: 585873
Foret MK, Lincoln R, Do Carmo S, et al. (2020) Connecting the "Dots": From Free Radical Lipid Autoxidation to Cell Pathology and Disease. Chemical Reviews
Kang MS, Aliaga AA, Shin M, et al. (2020) Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease. Molecular Psychiatry
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