Remy L. Brim, Ph.D.
Affiliations: | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
behavioral pharmacologyGoogle:
"Remy Brim"Mean distance: 16.18 (cluster 19) | S | N | B | C | P |
Parents
Sign in to add mentor| James H. Woods | grad student | 2011 | University of Michigan | |
| (Investigations into the therapeutic potential of a bacterial cocaine esterase for the treatment of cocaine toxicity and cocaine abuse.) | ||||
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Publications
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| Collins GT, Brim RL, Noon KR, et al. (2012) Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 342: 205-13 |
| Brim RL, Noon KR, Collins GT, et al. (2012) The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. The Journal of Pharmacology and Experimental Therapeutics. 340: 83-95 |
| Brim RL, Noon KR, Collins GT, et al. (2011) The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Molecular Pharmacology. 80: 1119-27 |
| Brim RL, Noon KR, Nichols J, et al. (2011) Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs. Drug and Alcohol Dependence. 119: 224-8 |
| Brim RL, Nance MR, Youngstrom DW, et al. (2010) A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Molecular Pharmacology. 77: 593-600 |
| Park JB, Kwon YM, Lee TY, et al. (2010) PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 142: 174-9 |
| Collins GT, Brim RL, Narasimhan D, et al. (2009) Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 445-55 |
| Gao D, Narasimhan DL, Macdonald J, et al. (2009) Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Molecular Pharmacology. 75: 318-23 |