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Ethan O. Perlstein, Ph.D.

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Chemical biology
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"Ethan Perlstein"
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Stuart L. Schreiber grad student 2006 Harvard
 (Assessing evolutionary conservation in Saccharomyces cerevisiae with small molecules.)

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Publications

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Iyer S, Sam FS, DiPrimio N, et al. (2019) Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG. Disease Models & Mechanisms
Iyer S, Mast JD, Tsang H, et al. (2019) Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches. Disease Models & Mechanisms
Lao JP, DiPrimio N, Prangley M, et al. (2018) Yeast Models Of Phosphomannomutase 2 Deficiency, A Congenital Disorder Of Glycosylation. G3 (Bethesda, Md.)
Granatosky EA, DiPrimio N, Pickering JRE, et al. (2018) GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts. Journal of Natural Products
Rodriguez TP, Mast JD, Hartl T, et al. (2018) Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Model of NGLY1 Deficiency. G3 (Bethesda, Md.)
Rainey MM, Korostyshevsky D, Lee S, et al. (2010) The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast. Genetics. 185: 1221-33
Chen BJ, Causton HC, Mancenido D, et al. (2009) Harnessing gene expression to identify the genetic basis of drug resistance. Molecular Systems Biology. 5: 310
Ruderfer DM, Roberts DC, Schreiber SL, et al. (2009) Using expression and genotype to predict drug response in yeast. Plos One. 4: e6907
de Bivort BL, Perlstein EO, Kunes S, et al. (2009) Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast. Journal of Molecular Evolution. 68: 490-7
Floto RA, Sarkar S, Perlstein EO, et al. (2007) Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy. 3: 620-2
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