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Jay H. Chang, Ph.D.

Affiliations: 
Office of New Drugs United States Food and Drug Administration, Silver Spring, MD, United States 
Area:
Anesthesia, Analgesia, Addiction
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"Jay Chang"
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Parents

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Jeffery L. Twiss grad student 1998-2005 University of South Carolina
 (Nerve growth factor -dependent signaling and transcription in neuronally differentiated PC12 cells.)
Bai Lu post-doc 2005-2008 NIH

Children

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Publications

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Willis D, Li KW, Zheng JQ, et al. (2010) Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons (The Journal of Neuroscience (2005) (778-791)) Journal of Neuroscience. 30
Huffaker SJ, Chen J, Nicodemus KK, et al. (2009) A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nature Medicine. 15: 509-18
Duan X, Chang JH, Ge S, et al. (2007) Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 130: 1146-58
van Niekerk EA, Willis DE, Chang JH, et al. (2007) Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proceedings of the National Academy of Sciences of the United States of America. 104: 12913-8
Twiss JL, Chang JH, Schanen NC. (2006) Pathophysiological mechanisms for actions of the neurotrophins. Brain Pathology (Zurich, Switzerland). 16: 320-32
Chang JH, Vuppalanchi D, van Niekerk E, et al. (2006) PC12 cells regulate inducible cyclic AMP (cAMP) element repressor expression to differentially control cAMP response element-dependent transcription in response to nerve growth factor and cAMP. Journal of Neurochemistry. 99: 1517-30
Willis D, Li KW, Zheng JQ, et al. (2005) Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 778-91
Lu B, Chang JH. (2004) Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory. Neuron Glia Biology. 1: 377-84
Espineda CE, Chang JH, Twiss J, et al. (2004) Repression of Na,K-ATPase beta1-subunit by the transcription factor snail in carcinoma. Molecular Biology of the Cell. 15: 1364-73
Chang JH, Mellon E, Schanen NC, et al. (2003) Persistent TrkA activity is necessary to maintain transcription in neuronally differentiated PC12 cells. The Journal of Biological Chemistry. 278: 42877-85
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