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David M. McKean, Ph.D.

Affiliations: 
2010 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Development
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"David McKean"
Mean distance: 19.37 (cluster 11)
 		SNBCP
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Parents

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Lee Niswander grad student 2010 University of Colorado, Denver
 (Cripto links GPI biosynthesis and TGFb signaling in forebrain development and holoprosencephaly.)

Children

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Publications

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Onoue K, Wakimoto H, Jiang J, et al. (2021) Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Mutation. Frontiers in Cardiovascular Medicine. 8: 639148
Hsieh A, Morton SU, Willcox JAL, et al. (2020) EM-mosaic detects mosaic point mutations that contribute to congenital heart disease. Genome Medicine. 12: 42
Jang MY, Tai AC, Patel PN, et al. (2019) Abstract 467: Identification of Novel Pathogenic Mutations in Non-Canonical RNA Splice Sites in Congenital Heart Disease Circulation Research. 125
DeLaughter DM, Bick AG, Wakimoto H, et al. (2016) Single-Cell Resolution of Temporal Gene Expression during Heart Development. Developmental Cell
McKean DM, Homsy J, Wakimoto H, et al. (2016) Loss of RNA expression and allele-specific expression associated with congenital heart disease. Nature Communications. 7: 12824
Homsy J, Zaidi S, Shen Y, et al. (2015) De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science (New York, N.Y.). 350: 1262-6
van den Boogaard M, Smemo S, Burnicka-Turek O, et al. (2014) A common genetic variant within SCN10A modulates cardiac SCN5A expression. The Journal of Clinical Investigation. 124: 1844-52
Christodoulou DC, Wakimoto H, Onoue K, et al. (2014) 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. The Journal of Clinical Investigation. 124: 1364-70
McKean DM, Niswander L. (2012) Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biology Open. 1: 874-83
Mao J, McKean DM, Warrier S, et al. (2010) The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development (Cambridge, England). 137: 3079-88
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