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Akiko Kochi, Ph.D.

Affiliations: 
2014 Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Metal Chelator-Based Chemotherapeutic Agents, Metallopeptides as Efficient and Selective Oxidation Catalysts, Metal-Based Reagents Toward Detoxification of H2O2 in Biological Systems
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"Akiko Kochi"
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Mi Hee Lim grad student 2014 University of Michigan
 (Development of Small Molecules to Target and Modulate Multiple Factors in the Neuropathogenesis of Alzheimer's Disease.)

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Publications

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Porter MR, Kochi A, Karty JA, et al. (2015) Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway. Chemical Science. 6: 1018-1026
Korshavn KJ, Jang M, Kwak YJ, et al. (2015) Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives. Scientific Reports. 5: 17842
Kochi A, Lee HJ, Vithanarachchi SM, et al. (2015) Inhibitory Activity of Curcumin Derivatives Towards Metal-Free and Metal-Induced Amyloid-β Aggregation. Current Alzheimer Research. 12: 415-23
Porter MR, Kochi A, Karty JA, et al. (2015) Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway Chemical Science. 6: 1018-1026
DeToma AS, Krishnamoorthy J, Nam Y, et al. (2014) Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species. Chemical Science. 5: 4851-4862
Geldenhuys WJ, Kochi A, Lin L, et al. (2014) Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease. Chembiochem : a European Journal of Chemical Biology
Lee HJ, Korshavn KJ, Kochi A, et al. (2014) Cholesterol and metal ions in Alzheimer's disease. Chemical Society Reviews. 43: 6672-82
Lee S, Zheng X, Krishnamoorthy J, et al. (2014) Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. Journal of the American Chemical Society. 136: 299-310
Liu Y, Kochi A, Pithadia AS, et al. (2013) Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications. Inorganic Chemistry. 52: 8121-30
Hyung SJ, DeToma AS, Brender JR, et al. (2013) Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proceedings of the National Academy of Sciences of the United States of America. 110: 3743-8
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