Leslie A. Dakin, Ph.D.

Affiliations: 
2005 Boston University, Boston, MA, United States 
Area:
synthetic organic chemistry
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"Leslie Dakin"
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James S. Panek grad student 2005 Boston University
 (Studies directed toward the total synthesis of leucascandrolide A, and, Catalytic asymmetric carbenoid insertions into the silicon -hydrogen bond catalyzed by chiral copper-(I) Schiff base complexes.)
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Publications

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Vaswani RG, Albrecht BK, Audia JE, et al. (2014) A practical synthesis of indoles via a Pd-catalyzed C-N ring formation. Organic Letters. 16: 4114-7
Yang B, Hird AW, Russell DJ, et al. (2012) Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO Bioorganic and Medicinal Chemistry Letters. 22: 4907-4911
MASSE CE, DAKIN LA, KNIGHT BS, et al. (2010) ChemInform Abstract: Lewis Acid-Mediated Carbocyclization Reactions of Chiral (E)-Crotylsilanes. Cheminform. 29: no-no
Su Q, Dakin LA, Panek JS. (2007) [4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A Journal of Organic Chemistry. 72: 2-24
Dakin LA, Panek JS. (2003) Enantioselective [4 + 2]-Annulation of Chiral Crotylsilanes: Application to the Synthesis of a C1-C22 Fragment of Leucascandrolide A Organic Letters. 5: 3995-3998
Langille NF, Dakin LA, Panek JS. (2003) A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane. Organic Letters. 5: 575-8
Langille NF, Dakin LA, Panek JS. (2003) A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane Organic Letters. 5: 575-578
Dakin LA, Langille NF, Panek JS. (2002) Synthesis of the C1'-C11' oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling. The Journal of Organic Chemistry. 67: 6812-5
Langille NF, Dakin LA, Panek JS. (2002) Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: Synthesis of disubstituted heterocycles Organic Letters. 4: 2485-2488
Dakin LA, Langille NF, Panek JS. (2002) Synthesis of the C1′-C11′ oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling Journal of Organic Chemistry. 67: 6812-6815
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