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Clara L. Kielkopf, Ph.D.

Affiliations: 
2000 California Institute of Technology, Pasadena, CA 
Area:
Protein Structure and Energetics; X-ray Crystallography
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"Clara Kielkopf"
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Parents

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Douglas C. Rees grad student 2000 Caltech
 (Structural basis of DNA recognition by synthetic ligands.)

Children

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Krystle J. McLaughlin grad student 2007-2011 Rochester

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Publications

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Maji D, Jenkins JL, Boutz PL, et al. (2024) Recurrent Neurodevelopmentally Associated Variants of the Pre-mRNA Splicing Factor U2AF2 Alter RNA Binding Affinities and Interactions. Biochemistry
Galardi JW, Bela VN, Jeffery N, et al. (2022) A UHM - ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. The Journal of Biological Chemistry. 102224
Glasser E, Maji D, Biancon G, et al. (2022) Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Research
Chatrikhi R, Feeney CF, Pulvino MJ, et al. (2021) A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chemical Biology
Maji D, Glasser E, Henderson S, et al. (2020) Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. The Journal of Biological Chemistry. 295: 17148-17157
Maji D, Glasser E, Henderson S, et al. (2020) Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. The Journal of Biological Chemistry
Warnasooriya C, Feeney CF, Laird KM, et al. (2020) A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation. Nucleic Acids Research
Maji D, Grossfield AM, Kielkopf CL. (2019) Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194440
Talkish J, Igel H, Hunter O, et al. (2019) Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction. Rna (New York, N.Y.)
Kennedy SD, Bauer WJ, Wang W, et al. (2019) Dynamic stacking of an expected branch point adenosine in duplexes containing pseudouridine-modified or unmodified U2 snRNA sites. Biochemical and Biophysical Research Communications
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