Erik W. Wilker, Ph.D.
Affiliations: | 2001 | University of Texas at Austin, Austin, Texas, U.S.A. |
Area:
Pharmacology and ToxicologyGoogle:
"Erik Wilker"Mean distance: 15925.2
Parents
Sign in to add mentorJohn DiGiovanni | grad student | 2001 | UT Austin | |
(Role of insulin -like growth factor I in mouse skin tumor promotion.) |
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Publications
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Simoneau A, Engel JL, Bandi M, et al. (2022) Ubiquitinated PCNA drives USP1 synthetic lethality in cancer. Molecular Cancer Therapeutics |
Shields JA, Meier SR, Bandi M, et al. (2022) VRK1 is a Synthetic Lethal Target in VRK2-deficient Glioblastoma. Cancer Research |
DeSelm L, Huck B, Lan R, et al. (2021) Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. Journal of Medicinal Chemistry |
Xiao Y, Huck BR, Lan R, et al. (2021) Discovery of 4-Aminopyrimidine Analogs as highly Potent Dual P70S6K/Akt Inhibitors. Bioorganic & Medicinal Chemistry Letters. 128352 |
Machl A, Wilker EW, Tian H, et al. (2016) M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. American Journal of Cancer Research. 6: 806-18 |
Banko MR, Allen JJ, Schaffer BE, et al. (2011) Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell. 44: 878-92 |
Yi C, Wilker EW, Yaffe MB, et al. (2008) Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2 Cancer Research. 68: 7932-7937 |
Lu J, Rho O, Wilker E, et al. (2007) Activation of epidermal akt by diverse mouse skin tumor promoters. Molecular Cancer Research : McR. 5: 1342-52 |
Charest A, Wilker EW, McLaughlin ME, et al. (2006) ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Research. 66: 7473-81 |
Wilker E, Lu J, Rho O, et al. (2005) Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion. Molecular Carcinogenesis. 44: 137-45 |