James Herrington

Affiliations: 
Merck Research Labs, Boston, MA, United States 
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"James Herrington"
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Publications

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Luo G, Chen L, Easton A, et al. (2019) Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry
Luo G, Chen L, Easton A, et al. (2018) Discovery of Indole- and Indazole-Acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry
Volgraf M, Sellers BD, Jiang Y, et al. (2016) Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. Journal of Medicinal Chemistry
Hanson JE, Meilandt WJ, Gogineni A, et al. (2014) Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8277-88
Shao PP, Ye F, Chakravarty PK, et al. (2013) Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide. Acs Medicinal Chemistry Letters. 4: 1064-8
Li XN, Herrington J, Petrov A, et al. (2013) The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. The Journal of Pharmacology and Experimental Therapeutics. 344: 407-16
Shao PP, Ye F, Chakravarty PK, et al. (2012) Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain. Journal of Medicinal Chemistry. 55: 9847-55
Swensen AM, Herrington J, Bugianesi RM, et al. (2012) Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels. Molecular Pharmacology. 81: 488-97
Herrington J, Solly K, Ratliff KS, et al. (2011) Identification of novel and selective Kv2 channel inhibitors. Molecular Pharmacology. 80: 959-64
Tyagarajan S, Chakravarty PK, Park M, et al. (2011) A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 21: 869-73
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