James L. Howard

Burroughs Wellcome Co., NC, United States 
"James Howard"
Mean distance: 16.16 (cluster 19)
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Owens SM, Pollard GT, Howard JL, et al. (2016) Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats. Acs Chemical Neuroscience
Runyon SP, Brieaddy LE, Mascarella SW, et al. (2010) Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity. Journal of Medicinal Chemistry. 53: 5290-301
Beardsley PM, Pollard GT, Howard JL, et al. (2010) Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats. Psychopharmacology. 210: 189-98
Navarro HA, Howard JL, Pollard GT, et al. (2009) Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. British Journal of Pharmacology. 156: 1178-84
Carroll FI, Fox BS, Kuhar MJ, et al. (2006) Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration. European Journal of Pharmacology. 553: 149-56
Carroll FI, Runyon SP, Abraham P, et al. (2004) Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers. Journal of Medicinal Chemistry. 47: 6401-9
Carroll I, Thomas JB, Dykstra LA, et al. (2004) Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist. European Journal of Pharmacology. 501: 111-9
Carroll FI, Pawlush N, Kuhar MJ, et al. (2004) Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. Journal of Medicinal Chemistry. 47: 296-302
Meade EA, Sznaidman M, Pollard GT, et al. (1998) Anxiolytic activity of analogues of 4-benzylamino-2-methyl-7H- pyrrolo[2,3-d]pyrimidines European Journal of Medicinal Chemistry. 33: 363-374
Rigdon GC, Norman MH, Cooper BR, et al. (1996) 1192U90 in animal tests that predict antipsychotic efficacy, anxiolysis, and extrapyramidal side effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 231-42
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