Michael J. Federle, Ph.D.

Affiliations: 
2002 Emory University, Atlanta, GA 
Area:
Molecular Biology, Microbiology Biology
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"Michael Federle"

Parents

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June R. Scott grad student 2002 Emory
 (Uncovering the Streptococcus pyogenes CovRS global regulator of virulence: Describing a regulon and an unusual mechanism for repression.)
Bonnie L. Bassler post-doc 2002-2008 Princeton (Chemistry Tree)
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Publications

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Hu D, Laczkovich I, Federle MJ, et al. (2023) Identification and Characterization of Negative Regulators of Rgg1518 Quorum Sensing in Streptococcus pneumoniae. Journal of Bacteriology. e0008723
Nepomuceno VM, Tylor KM, Carlson S, et al. (2023) A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiology Spectrum. e0527922
Rued BE, Anderson CM, Federle MJ. (2022) The Proteomic and Transcriptomic Landscapes Altered by Rgg2/3 Activity in Streptococcus pyogenes. Journal of Bacteriology. 204: e0017522
Chang JC, Wilkening RV, Rahbari KM, et al. (2022) Quorum Sensing Regulation of a Major Facilitator Superfamily Transporter Affects Multiple Streptococcal Virulence Factors. Journal of Bacteriology. e0017622
Laczkovich I, Mangano K, Shao X, et al. (2022) Discovery of Unannotated Small Open Reading Frames in Streptococcus pneumoniae D39 Involved in Quorum Sensing and Virulence Using Ribosome Profiling. Mbio. e0124722
Woo JKK, McIver KS, Federle MJ. (2021) Carbon catabolite repression on the Rgg2/3 quorum sensing system in Streptococcus pyogenes is mediated by PTS and Mga. Molecular Microbiology
Capodagli GC, Tylor KM, Kaelber JT, et al. (2020) Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay. Proceedings of the National Academy of Sciences of the United States of America
Bushin LB, Covington BC, Rued BE, et al. (2020) Discovery and Biosynthesis of Streptosactin, a Sactipeptide with an Alternative Topology Encoded by Commensal Bacteria in the Human Microbiome. Journal of the American Chemical Society
Gogos A, Federle MJ. (2020) Colonization of the murine oropharynx by is governed by the Rgg2/3 quorum sensing system. Infection and Immunity
Cook LCC, Chatterjee N, Li Y, et al. (2019) Transcriptomic Analysis of Streptococcus pyogenes Colonizing the Vaginal Mucosa Identifies , an MtsR-Regulated Adhesin Involved in Heme Utilization. Mbio. 10
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