Jeremy A. Yethon, Ph.D.

Affiliations: 
2001 University of Guelph (Canada), Guelph, Ontario, Canada 
Area:
Microbiology Biology
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"Jeremy Yethon"

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Chris Whitfield grad student 2001 University of Guelph (Canada)
 (Lipopolysaccharide synthesis and characterization of a core oligosaccharide kinase essential to outer membrane stability.)
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Publications

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Yethon JA, Whitfield C. (2001) Lipopolysaccharide as a target for the development of novel therapeutics in gram-negative bacteria. Current Drug Targets. Infectious Disorders. 1: 91-106
Yethon JA, Whitfield C. (2001) Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability. The Journal of Biological Chemistry. 276: 5498-504
Yethon JA, Vinogradov E, Perry MB, et al. (2000) Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Journal of Bacteriology. 182: 5620-3
Yethon JA, Gunn JS, Ernst RK, et al. (2000) Salmonella enterica serovar typhimurium waaP mutants show increased susceptibility to polymyxin and loss of virulence In vivo. Infection and Immunity. 68: 4485-91
Amor PA, Yethon JA, Monteiro MA, et al. (1999) Assembly of the K40 antigen in Escherichia coli: identification of a novel enzyme responsible for addition of L-serine residues to the glycan backbone and its requirement for K40 polymerization. Journal of Bacteriology. 181: 772-80
Whitfield C, Heinrichs DE, Yethon JA, et al. (1999) Assembly of the R1-type core oligosaccharide of Escherichia coli lipopolysaccharide Journal of Endotoxin Research. 5: 151-156
Whitfield C, Heinrichs DE, Yethon JA, et al. (1999) Assembly of the R1-type core oligosaccharide of Escherichia coli lipopolysaccharide Journal of Endotoxin Research. 5: 151-156
Heinrichs DE, Yethon JA, Amor PA, et al. (1998) The assembly system for the outer core portion of R1- and R4-type lipopolysaccharides of Escherichia coli. The R1 core-specific beta-glucosyltransferase provides a novel attachment site for O-polysaccharides. The Journal of Biological Chemistry. 273: 29497-505
Heinrichs DE, Yethon JA, Whitfield C. (1998) Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Molecular Microbiology. 30: 221-32
Yethon JA, Heinrichs DE, Monteiro MA, et al. (1998) Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide and their role in the formation of a stable outer membrane. The Journal of Biological Chemistry. 273: 26310-6
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