H. Brent Clark, MD PhD
Affiliations: | Laboratory Medicine and Pathobiology | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
cerebellar ataxia both in human disease and experimental animal modelsWebsite:
http://pathology.umn.edu/about/faculty/clark/home.htmlGoogle:
"H. Clark"Mean distance: 106866
Cross-listing: Neuropathology Tree
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Publications
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| Mouro Pinto R, Arning L, Giordano JV, et al. (2020) Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1. Human Molecular Genetics |
| Friedrich J, Kordasiewicz HB, O'Callaghan B, et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. Jci Insight. 3 |
| Ayhan F, Perez BA, Shorrock HK, et al. (2018) SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. The Embo Journal |
| Ingram MA, Orr HT, Clark HB. (2012) Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias. Brain Research Bulletin. 88: 33-42 |
| Zu T, Gibbens B, Doty NS, et al. (2011) Non-ATG-initiated translation directed by microsatellite expansions. Proceedings of the National Academy of Sciences of the United States of America. 108: 260-5 |
| Iltis I, Hutter D, Bushara KO, et al. (2010) (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2. Brain Research. 1358: 200-10 |
| Oz G, Nelson CD, Koski DM, et al. (2010) Noninvasive detection of presymptomatic and progressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3831-8 |
| Serra HG, Duvick L, Zu T, et al. (2006) RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice. Cell. 127: 697-708 |
| He Y, Zu T, Benzow KA, et al. (2006) Targeted deletion of a single Sca8 ataxia locus allele in mice causes abnormal gait, progressive loss of motor coordination, and Purkinje cell dendritic deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9975-82 |
| Moseley ML, Zu T, Ikeda Y, et al. (2006) Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8. Nature Genetics. 38: 758-69 |