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John B. Mangrum, Ph.D.

Affiliations: 
2010 Chemistry Virginia Commonwealth University, Richmond, VA, United States 
Area:
Inorganic Chemistry
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Nicholas P. Farrell grad student 2010 VCU
 (Electrospray ionization mass spectrometry for the characterization of covalent and noncovalent polynuclear platinum compounds interacting with bio-molecules.)

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Spell SR, Mangrum JB, Peterson EJ, et al. (2016) Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists. Chemical Communications (Cambridge, England)
Komeda S, Qu Y, Mangrum JB, et al. (2016) The phosphate clamp as recognition motif in platinum-DNA interactions Inorganica Chimica Acta
Mangrum JB, Martin EJ, Brophy DF, et al. (2014) Intact stable isotope labeled plasma proteins from the SILAC-labeled HepG2 secretome. Proteomics
Mangrum JB, Engelmann BJ, Peterson EJ, et al. (2014) A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding. Chemical Communications (Cambridge, England). 50: 4056-8
Mangrum JB, Zgani I, Tsotsoros SD, et al. (2013) Zinc finger peptide cleavage by a dinuclear platinum compound. Chemical Communications (Cambridge, England). 49: 6986-8
Demicheli C, Frézard F, Pereira FA, et al. (2011) Interaction of arsenite with a zinc finger CCHC peptide: evidence for formation of an As-Zn-peptide mixed complex. Journal of Inorganic Biochemistry. 105: 1753-8
Zhou Q, Qu Y, Mangrum JB, et al. (2011) DNA alkylation with N-methylquinolinium quinone methide to N2-dG adducts resulting in extensive stops in primer extension with DNA polymerases and subsequent suppression of GFP expression in A549 cells. Chemical Research in Toxicology. 24: 402-11
Mangrum JB, Farrell NP. (2010) Excursions in polynuclear platinum DNA binding. Chemical Communications (Cambridge, England). 46: 6640-50
De Paula QA, Liu Q, Almaraz E, et al. (2009) Reactions of palladium and gold complexes with zinc-thiolate chelates using electrospray mass spectrometry and X-ray diffraction: Molecular identification of [Pd(bme-dach)], [Au(bme-dach]+ and [ZnCl(bme-dach)]2Pd Dalton Transactions. 10896-10903
de Paula QA, Mangrum JB, Farrell NP. (2009) Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M=Pt, Pd, Au). Journal of Inorganic Biochemistry. 103: 1347-54
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