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Raj K. Malla, Ph.D.

Affiliations: 
2011 Chemistry and Biochemistry University of Missouri - Saint Louis 
Area:
Organic Chemistry
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Christopher D. Spilling grad student 2011 University of Missouri - Saint Louis
 (Synthesis of (+/-)-Cyclophostin, (+/-)-Cyclipostin P, Their Phosphonate Analogs and New Chemistry of Vinyl Phosphonates.)

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Publications

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Vasilieva E, Dutta S, Malla RK, et al. (2015) Rat hormone sensitive lipase inhibition by cyclipostins and their analogs. Bioorganic & Medicinal Chemistry. 23: 944-52
Spilling CD, Malla RK. (2015) Synthesis of non-racemic α-hydroxyphosphonates via asymmetric phospho-aldol reaction. Topics in Current Chemistry. 361: 83-136
Malla RK, Ridenour JN, Spilling CD. (2014) Relay cross metathesis reactions of vinylphosphonates. Beilstein Journal of Organic Chemistry. 10: 1933-41
Point V, Malla RK, Carrière F, et al. (2013) Enantioselective inhibition of microbial lipolytic enzymes by nonracemic monocyclic enolphosphonate analogues of cyclophostin. Journal of Medicinal Chemistry. 56: 4393-401
Point V, Malla RK, Diomande S, et al. (2012) Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases. Journal of Medicinal Chemistry. 55: 10204-19
Malla RK, Bandyopadhyay S, Spilling CD, et al. (2011) The first total synthesis of (±)-cyclophostin and (±)-cyclipostin P: inhibitors of the serine hydrolases acetyl cholinesterase and hormone sensitive lipase. Organic Letters. 13: 3094-7
Dutta S, Malla RK, Bandyopadhyay S, et al. (2010) Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase. Bioorganic & Medicinal Chemistry. 18: 2265-74
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