Nicholas H. Varvel, PhD
Affiliations: | 2013- | Pharmacology | Emory University, Atlanta, GA |
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"Nicholas Varvel"Mean distance: 14.23 (cluster 6) | S | N | B | C | P |
Parents
Sign in to add mentor| Karl Herrup | grad student | 2003-2008 | Case Western Reserve University, School of Medicine | |
| Bruce T. Lamb | grad student | 2003-2008 | Case Western | |
| (The role of beta -amyloid and inflammation in neuronal cell cycle events in Alzheimer's disease mouse models.) | ||||
| Mathias Jucker | post-doc | 2009-2013 | University of Tuebingen, Germany | |
| Ray Dingledine | post-doc | 2013-2020 | Emory | |
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Publications
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| Alemán-Ruiz C, Wang W, Dingledine R, et al. (2023) Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus. Scientific Reports. 13: 5651 |
| Varvel NH, Amaradhi R, Espinosa-Garcia C, et al. (2022) Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology. 224: 109356 |
| Varvel NH, Espinosa-Garcia C, Hunter-Chang S, et al. (2020) Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Varvel NH, Ransohoff RM, Neher JJ. (2019) Functional Analysis of Brain-Engrafted Monocytes After Microglia Ablation in Mouse Models. Methods in Molecular Biology (Clifton, N.J.). 2034: 293-301 |
| Manji Z, Rojas A, Wang W, et al. (2019) 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad |
| Rojas A, Chen D, Ganesh T, et al. (2018) The COX-2/prostanoid signaling cascades in seizure disorders. Expert Opinion On Therapeutic Targets |
| Varvel NH, Neher JJ, Bosch A, et al. (2016) Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proceedings of the National Academy of Sciences of the United States of America |
| Varvel NH, Grathwohl SA, Degenhardt K, et al. (2015) Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease. The Journal of Experimental Medicine. 212: 1803-9 |
| Varvel NH, Jiang J, Dingledine R. (2015) Candidate drug targets for prevention or modification of epilepsy. Annual Review of Pharmacology and Toxicology. 55: 229-47 |
| Dingledine R, Varvel NH, Dudek FE. (2014) When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Advances in Experimental Medicine and Biology. 813: 109-22 |