Nicholas H. Varvel, PhD

Affiliations: 
2013- Pharmacology Emory University, Atlanta, GA 
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"Nicholas Varvel"
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Bruce T. Lamb grad student 2008 Case Western
 (The role of beta -amyloid and inflammation in neuronal cell cycle events in Alzheimer's disease mouse models.)
Ray Dingledine post-doc 2013- Emory
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Publications

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Manji Z, Rojas A, Wang W, et al. (2019) 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad
Rojas A, Chen D, Ganesh T, et al. (2018) The COX-2/prostanoid signaling cascades in seizure disorders. Expert Opinion On Therapeutic Targets
Varvel NH, Neher JJ, Bosch A, et al. (2016) Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proceedings of the National Academy of Sciences of the United States of America
Varvel NH, Grathwohl SA, Degenhardt K, et al. (2015) Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease. The Journal of Experimental Medicine. 212: 1803-9
Varvel NH, Jiang J, Dingledine R. (2015) Candidate drug targets for prevention or modification of epilepsy. Annual Review of Pharmacology and Toxicology. 55: 229-47
Dingledine R, Varvel NH, Dudek FE. (2014) When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Advances in Experimental Medicine and Biology. 813: 109-22
Bhaskar K, Maphis N, Xu G, et al. (2014) Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. Neurobiology of Disease. 62: 273-85
Varvel NH, Grathwohl SA, Baumann F, et al. (2012) Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 18150-5
Hamaguchi T, Eisele YS, Varvel NH, et al. (2012) The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropathologica. 123: 31-7
Wilkinson BL, Cramer PE, Varvel NH, et al. (2012) Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiology of Aging. 33: 197.e21-32
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