Gregory D. Hurlbut, Ph.D.

Affiliations: 
Applied Discovery Research Genzyme, Cambridge, MA, United States 
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"Gregory Hurlbut"
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Treleaven CM, Tamsett TJ, Bu J, et al. (2012) Gene transfer to the CNS is efficacious in immune-primed mice harboring physiologically relevant titers of anti-AAV antibodies. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1713-23
Nietupski JB, Hurlbut GD, Ziegler RJ, et al. (2011) Systemic administration of AAV8-α-galactosidase A induces humoral tolerance in nonhuman primates despite low hepatic expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1999-2011
Hurlbut GD, Ziegler RJ, Nietupski JB, et al. (2010) Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1983-94
Hurlbut GD, Kankel MW, Artavanis-Tsakonas S. (2009) Nodal points and complexity of Notch-Ras signal integration. Proceedings of the National Academy of Sciences of the United States of America. 106: 2218-23
Kankel MW, Hurlbut GD, Upadhyay G, et al. (2007) Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics. 177: 2493-505
Hurlbut GD, Kankel MW, Lake RJ, et al. (2007) Crossing paths with Notch in the hyper-network. Current Opinion in Cell Biology. 19: 166-75
Mourikis P, Hurlbut GD, Artavanis-Tsakonas S. (2006) Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 103: 1307-12
Kuperwasser C, Hurlbut GD, Kittrell FS, et al. (2000) Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. The American Journal of Pathology. 157: 2151-9
Kuperwasser C, Pinkas J, Hurlbut GD, et al. (2000) Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment. Cancer Research. 60: 2723-9
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