Ke-He Ruan

Affiliations: 
The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Biochemistry, General Biophysics, Pharmacology
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"Ke-He Ruan"
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Publications

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Li Y, Li QY, Ling QL, et al. (2019) A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A and exhibiting powerful anti-bleeding functions. Journal of Cellular and Molecular Medicine
Li Y, Xu A, Ling Q, et al. (2018) Advances in extracellular ligand recognition sites on prostanoid receptors. Future Medicinal Chemistry
Akasaka H, Thaliachery N, Zheng X, et al. (2017) The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2-and retaining PGE1-mediated signaling in live cells. Archives of Biochemistry and Biophysics
Chen Y, Fujita T, Zhang D, et al. (2011) Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. The Journal of Biological Chemistry. 286: 32575-85
Mohite A, Chillar A, So SP, et al. (2011) Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression. Biochemistry. 50: 1691-9
Chillar A, Wu J, Cervantes V, et al. (2010) Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry. 49: 6365-74
Chillar A, Wu J, Cervantes V, et al. (2010) Characterization Of The Ligand-Free Constitutive Activity Of The Thromboxane A2 Receptor By The Integrated Approaches Of Nmr Spectroscopy And A Recombinant Receptor Journal of Back and Musculoskeletal Rehabilitation
Ruan KH, Cervantes V, So SP. (2009) Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. Protein Engineering, Design & Selection : Peds. 22: 733-40
Ruan KH, Cervantes V, Wu J. (2009) Ligand-specific conformation determines agonist activation and antagonist blockade in purified human thromboxane A2 receptor. Biochemistry. 48: 3157-65
Ruan KH, So SP, Wu H, et al. (2008) Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential. Archives of Biochemistry and Biophysics. 480: 41-50
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