Samantha Q. Wales, Ph.D.
Affiliations: | 2008 | Pharmacology and Experimental Therapeutics | University of Maryland School of Medicine, Baltimore, MD, United States |
Area:
Neuroscience Biology, Cell Biology, Molecular BiologyGoogle:
"Samantha Wales"Mean distance: 30533.1
Parents
Sign in to add mentor| Laure Aurelian | grad student | 2008 | University of Maryland Medical School | |
| (Molecular mechanisms of neuroprotection by the herpes simplex virus type 2 gene ICP10PK.) | ||||
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Publications
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| Wales SQ, Laing JM, Chen L, et al. (2008) ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+. Gene Therapy. 15: 1397-409 |
| Laing JM, Golembewski EK, Wales SQ, et al. (2008) Growth-compromised HSV-2 vector Delta RR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades. Journal of Neuroscience Research. 86: 378-91 |
| Wales SQ, Li B, Laing JM, et al. (2007) The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation. Journal of Neurochemistry. 103: 365-79 |
| Golembewski EK, Wales SQ, Aurelian L, et al. (2007) The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity. Experimental Neurology. 203: 381-93 |
| Gober MD, Wales SQ, Hunter JC, et al. (2005) Stress up-regulates neuronal expression of the herpes simplex virus type 2 large subunit of ribonucleotide reductase (R1; ICP10) by activating activator protein 1. Journal of Neurovirology. 11: 329-36 |
| Gober MD, Wales SQ, Aurelian L. (2005) Herpes simplex virus type 2 encodes a heat shock protein homologue with apoptosis regulatory functions. Frontiers in Bioscience : a Journal and Virtual Library. 10: 2788-803 |
| Wales SQ, Smith CC, Wachsman M, et al. (2004) Performance and use of a ribonucleotide reductase herpes simplex virus type-specific serological assay. Clinical and Diagnostic Laboratory Immunology. 11: 42-9 |