Holly B. Kordasiewicz, Ph.D.
Affiliations: | 2006 | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
Neuroscience BiologyGoogle:
"Holly Kordasiewicz"Mean distance: 35622
Parents
Sign in to add mentor| Christopher M. Gomez | grad student | 2006 | UMN | |
| (C-termini of P/Q-type calcium channel alpha1A subunits translocate to nuclei and mediate spinocerebellar ataxia type 6 toxicity.) | ||||
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Publications
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| Fienko S, Landles C, Sathasivam K, et al. (2022) Alternative processing of human HTT mRNA with implications for Huntington's disease therapeutics. Brain : a Journal of Neurology |
| O'Callaghan B, Hofstra B, Handler HP, et al. (2020) Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment. Molecular Therapy. Nucleic Acids. 21: 1006-1016 |
| Minikel EV, Zhao HT, Le J, et al. (2020) Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints. Nucleic Acids Research |
| Leavitt BR, Kordasiewicz HB, Schobel SA. (2020) Huntingtin-Lowering Therapies for Huntington Disease: A Review of the Evidence of Potential Benefits and Risks. Jama Neurology |
| Poplawski SG, Garbett KA, McMahan RL, et al. (2020) An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement. Molecular Therapy. Nucleic Acids. 19: 1399-1412 |
| Mazur C, Powers B, Zasadny K, et al. (2019) Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging. Jci Insight. 4 |
| Raymond GJ, Zhao HT, Race B, et al. (2019) Antisense oligonucleotides extend survival of prion-infected mice. Jci Insight. 5 |
| Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, et al. (2019) Targeting Huntingtin Expression in Patients with Huntington's Disease. The New England Journal of Medicine |
| Self WK, Schoch KM, Alex J, et al. (2018) Protein production is an early biomarker for RNA-targeted therapies. Annals of Clinical and Translational Neurology. 5: 1492-1504 |
| Friedrich J, Kordasiewicz HB, O'Callaghan B, et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. Jci Insight. 3 |