Holly B. Kordasiewicz, Ph.D.

2006 University of Minnesota, Twin Cities, Minneapolis, MN 
Neuroscience Biology
"Holly Kordasiewicz"
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Christopher M. Gomez grad student 2006 UMN
 (C-termini of P/Q-type calcium channel alpha1A subunits translocate to nuclei and mediate spinocerebellar ataxia type 6 toxicity.)
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Skotte NH, Southwell AL, Østergaard ME, et al. (2014) Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients. Plos One. 9: e107434
Southwell AL, Skotte NH, Kordasiewicz HB, et al. (2014) In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 2093-106
Arnold ES, Ling SC, Huelga SC, et al. (2013) ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proceedings of the National Academy of Sciences of the United States of America. 110: E736-45
Yu D, Pendergraff H, Liu J, et al. (2012) Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell. 150: 895-908
Kordasiewicz HB, Stanek LM, Wancewicz EV, et al. (2012) Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 74: 1031-44
Polymenidou M, Lagier-Tourenne C, Hutt KR, et al. (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nature Neuroscience. 14: 459-68
Miller TM, Smith RA, Kordasiewicz H, et al. (2008) Gene-targeted therapies for the central nervous system. Archives of Neurology. 65: 447-51
Boulware MI, Kordasiewicz H, Mermelstein PG. (2007) Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9941-50
Kordasiewicz HB, Gomez CM. (2007) Molecular pathogenesis of spinocerebellar ataxia type 6. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 4: 285-94
Raike RS, Kordasiewicz HB, Thompson RM, et al. (2007) Dominant-negative suppression of Cav2.1 currents by alpha(1)2.1 truncations requires the conserved interaction domain for beta subunits. Molecular and Cellular Neurosciences. 34: 168-77
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