Nicole M. Wydeven, Ph.D.

Affiliations: 
2014 Pharmacology University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Pharmacology, General Biophysics, Cell Biology
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"Nicole Wydeven"
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Kevin Wickman grad student 2014 UMN
 (Molecular mechanisms of inhibitory signaling in the heart and brain.)
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Publications

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Wydeven N, Marron Fernandez de Velasco E, Du Y, et al. (2014) Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297. Proceedings of the National Academy of Sciences of the United States of America. 111: 10755-60
Krogh KA, Wydeven N, Wickman K, et al. (2014) HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways. Journal of Neurochemistry. 130: 642-56
Wydeven N, Posokhova E, Xia Z, et al. (2014) RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. The Journal of Biological Chemistry. 289: 2440-9
Fajardo-Serrano A, Wydeven N, Young D, et al. (2013) Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. Hippocampus. 23: 1231-45
Wydeven N, Young D, Mirkovic K, et al. (2012) Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proceedings of the National Academy of Sciences of the United States of America. 109: 21492-7
Posokhova E, Wydeven N, Allen KL, et al. (2010) RGS6/Gβ5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Circulation Research. 107: 1350-4
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