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Juan M. Schvartzman, Ph.D.

Affiliations: 
2004-2011 Weill Cornell Medical College, New York, NY, United States 
 2004-2011 Cancer Biology & Genetics Sloan Kettering Institute, New York, NY, United States 
 2011-2014 Internal Medicine Montefiore Medical Center, New York, NY, United States 
 2014-2022 Department of Medicine Memorial Sloan Kettering Cancer Center, Rockville Centre, NY, United States 
 2015-2022 Cancer Biology & Genetics Sloan Kettering Institute, New York, NY, United States 
 2022- Department of Medicine Columbia College of Physicians and Surgeons 
Area:
Molecular Biology, Oncology
Website:
http://schvartzmanlab.org
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Parents

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Robert Benezra grad student 2004-2011 Weill Cornell Medical College
 (Mad2 upregulation mediates the chromosome instability imparted by Rb pathway inhibition.)
Craig B. Thompson post-doc 2015-2022 Memorial Sloan Kettering Cancer Center (Chemistry Tree)

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Publications

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Schvartzman JM, Reuter VP, Koche RP, et al. (2019) 2-hydroxyglutarate inhibits MyoD-mediated differentiation by preventing H3K9 demethylation. Proceedings of the National Academy of Sciences of the United States of America
Schvartzman JM, Thompson CB, Finley LWS. (2018) Metabolic regulation of chromatin modifications and gene expression. The Journal of Cell Biology
Schvartzman JM, Duijf PH, Sotillo R, et al. (2011) Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell. 19: 701-14
Sotillo R, Schvartzman JM, Socci ND, et al. (2010) Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature. 464: 436-40
Schvartzman JM, Sotillo R, Benezra R. (2010) Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nature Reviews. Cancer. 10: 102-15
Sotillo R, Schvartzman JM, Benezra R. (2009) Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity. Cancer Cell. 16: 451-2
Diaz-Rodríguez E, Sotillo R, Schvartzman JM, et al. (2008) Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 16719-24
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