Lihong Zhan, Ph.D.
Affiliations: | 2015 | Molecular and Cellular Pharmacology | University of Wisconsin, Madison, Madison, WI |
Area:
Genetics, Cell BiologyGoogle:
"Lihong Zhan"Mean distance: 26716.5
Parents
Sign in to add mentor| Randal Tibbetts | grad student | 2015 | UW Madison | |
| (Genetic screening and characterization of modifiers in a Drosophila ALS model of TDP-43 neurotoxicity.) | ||||
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Publications
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| Telpoukhovskaia MA, Liu K, Sayed FA, et al. (2020) Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. Scientific Reports. 10: 13688 |
| Zhan L, Krabbe G, Du F, et al. (2019) Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain. Plos Biology. 17: e3000134 |
| Sayed FA, Telpoukhovskaia M, Kodama L, et al. (2018) Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proceedings of the National Academy of Sciences of the United States of America |
| Kim SH, Stiles SG, Feichtmeier JM, et al. (2017) Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS. Human Molecular Genetics |
| Krabbe G, Minami SS, Etchegaray JI, et al. (2017) Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America |
| Zhan L, Xie Q, Tibbetts RS. (2015) Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration. Human Molecular Genetics. 24: 757-72 |
| Zhan L, Hanson KA, Kim SH, et al. (2013) Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila. Plos One. 8: e57214 |
| Kim SH, Zhan L, Hanson KA, et al. (2012) High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity. Human Molecular Genetics. 21: 4845-56 |
| Shanware NP, Hutchinson JA, Kim SH, et al. (2011) Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability. The Journal of Biological Chemistry. 286: 12766-74 |
| Shanware NP, Zhan L, Hutchinson JA, et al. (2010) Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. Plos One. 5: e12173 |