Ian D. Coombs

Affiliations: 
University College London, London, United Kingdom 
Area:
Ionotropic glutamate receptors
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"Ian Coombs"
Mean distance: 14.66 (cluster 11)
 
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Publications

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Bats C, Coombs ID, Farrant M, et al. (2024) α-Bungarotoxin labelling of AMPA receptor-associated TARPs in living neurons. Neuroscience
Coombs ID, Farrant M. (2023) An unexpected role for a glutamate receptor. Science (New York, N.Y.). 382: 1363-1364
Coombs I, Bats C, Sexton CA, et al. (2023) Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM. Elife. 12
Coombs ID, Ziobro J, Krotov V, et al. (2022) A gain-of-function GRIA2 variant associated with neurodevelopmental delay and seizures: functional characterization and targeted treatment. Epilepsia
Coombs ID, Sexton CA, Cull-Candy SG, et al. (2022) Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance. Molecular Pharmacology. 101: 343-356
Coombs ID, Cull-Candy SG. (2021) Single-channel mechanisms underlying the function, diversity and plasticity of AMPA receptors. Neuropharmacology. 108781
Coombs ID, Soto D, McGee TP, et al. (2019) Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nature Communications. 10: 4312
Coombs ID, MacLean DM, Jayaraman V, et al. (2017) Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation. Cell Reports. 20: 1123-1135
Coombs I, Tarasiuk A, Marconi L, et al. (2017) Multiple Subconductance States of Tarped AMPA Receptors Revealed by Slow Dissociation of Antagonist Biophysical Journal. 112: 418a
Coombs ID, Soto D. (2016) Using electrophysiology to study synaptic and extrasynaptic ionotropic receptors in hippocampal neurons Neuromethods. 110: 313-355
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