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Michael H. B. Stowell, PhD

Affiliations: 
University of Colorado, Boulder, Boulder, CO, United States 
Area:
Structure and Mechanism at the Chemical Synapse
Website:
http://dosequis.colorado.edu/
Google:
"Michael Stowell"
Bio:

https://www.proquest.com/openview/b7f585f2a00907bdb830362c6f8f202f/1
Structure and Mechanism at the Chemical Synapse.> Our research is focused on molecular and supramolecular structures that facilitate communication between neurons at the chemical synapse. We are particularly interested in the architectural arrangement of signaling molecules and characterizing the ways in which such molecular assemblies are formed and undergo changes during synaptic transmission and modulation. Our approach is to investigate individual proteins using x-ray and electron crystallographic methods, and combine this information with 3-D reconstructions of large assemblies along with tomographic analysis of the intact chemical synapse.
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Mean distance: 18.79 (cluster 51)
 		SNBCP
Cross-listing: Chemistry Tree

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Parents

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Sunney I. Chan grad student 1997 Caltech (Chemistry Tree)
Douglas C. Rees grad student 1997 Caltech (Chemistry Tree)
 (Ekmageion)
Yoshinori Fujiyoshi post-doc Kyoto University
Nigel Unwin post-doc Cambridge

Children

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Takashi Daniel Yoshida Kozai research assistant 2002-2005 University of Pittsburgh
Christopher P. Arthur grad student 2007 CU Boulder
Thomas Z. Armel grad student 2009 CU Boulder
Hsin-Jui Wu grad student 2013 CU Boulder

Collaborators

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Publications

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Maity K, Heumann JM, McGrath AP, et al. (2020) cryo-EM Structure of Rice OSCA1.2 Elucidates the Mechanical Basis of Membrane Hyperosmolality Gating in Plants Biophysical Journal. 118: 211a
Adams DJ, Arthur CP, Stowell MH. (2015) Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse. Scientific Reports. 5: 13659
Basta T, Wu HJ, Morphew MK, et al. (2014) Self-assembled lipid and membrane protein polyhedral nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. 111: 670-4
Pieper U, Schlessinger A, Kloppmann E, et al. (2013) Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nature Structural & Molecular Biology. 20: 135-8
Arthur CP, Dean C, Pagratis M, et al. (2010) Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons. Neuroscience. 167: 135-42
Arthur CP, Stowell MH. (2007) Structure of synaptophysin: a hexameric MARVEL-domain channel protein. Structure (London, England : 1993). 15: 707-14
Arthur CP, Serrell DB, Pagratis M, et al. (2007) Electron tomographic methods for studying the chemical synapse. Methods in Cell Biology. 79: 241-57
Yeh AP, McMillan A, Stowell MH. (2006) Rapid and simple protein-stability screens: application to membrane proteins. Acta Crystallographica. Section D, Biological Crystallography. 62: 451-7
Tierney ML, Osborn KE, Milburn PJ, et al. (2004) Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays. The Journal of Experimental Biology. 207: 3581-90
Marks B, Stowell MH, Vallis Y, et al. (2001) GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature. 410: 231-5
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