Felice Tirone, Laurea (1979) and PhD (obtained in 1987)

Cell Biology and Neurobiology National Research Council, Rome Italy 
"Felice Tirone"

Felice Tirone at the beginning of his career has performed studies of neurochemistry at the University of Milan, Department of Pharmacology, during his experimental thesis for the degree in Biological Sciences and for a period as Ph.D student, in the laboratory of A.Groppetti. During this period he has contributed to clarify issues concerning the function of neuronal dopaminergic and serotoninergic circuits of central nervous system.

Since 1986 he has developed the interest for gene regulation during the development of the nervous system, a topic that he investigated for three and half years (end 1985 to beginning 1989) in the laboratory of Eric Shooter, at the Dept. of Neurobiology della Stanford University, USA.

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Mean distance: 15.79 (cluster 11)
Cross-listing: Chemistry Tree - Cell Biology Tree

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Micheli L, Leonardi L, Conti F, et al. (2011) PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB. The Journal of Biological Chemistry. 286: 5691-707
Farioli-Vecchioli S, Saraulli D, Costanzi M, et al. (2009) Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice. Plos One. 4: e8339
Farioli-Vecchioli S, Tanori M, Micheli L, et al. (2007) Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2215-25
Micheli L, Leonardi L, Conti F, et al. (2005) PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Molecular and Cellular Biology. 25: 2242-59
Canzoniere D, Farioli-Vecchioli S, Conti F, et al. (2004) Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3355-69
Iacopetti P, Barsacchi G, Tirone F, et al. (1996) Expression of the PC4 gene in the developing rat nervous system. Brain Research. 707: 293-7
Iacopetti P, Barsacchi G, Tirone F, et al. (1994) Developmental expression of PC3 gene is correlated with neuronal cell birthday. Mechanisms of Development. 47: 127-37
Bradbury A, Possenti R, Shooter EM, et al. (1991) Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. Proceedings of the National Academy of Sciences of the United States of America. 88: 3353-7
Tirone F, Shooter EM. (1989) Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene. Proceedings of the National Academy of Sciences of the United States of America. 86: 2088-92
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